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LM Neuropsyc
Memory Lecture Nine
| Question | Answer |
|---|---|
| Memory is represented by a change in the shape of the postsynaptic ______ (where synaptic input is received_ | spine |
| How are learning and memory related? | Learning is the process of acquiring new information and memory refers to the persistence of learning (retaining information) |
| Memory impairment is often referred to as _____, which may reflect a deficit in remembering the past or a deficit in forming new memories | amnesia |
| What are the three stages of memory? | Ecoding, storage and retreival |
| What stage of memory is this? creates and maintains "permanent" record of the information encoded | Storage |
| What stage of memory is this? processing of incoming information to be stored where there is both aquisition and consolidation | Encoding |
| Is this aquisition of consolidation (as part of encoding? when they register the inputs | Aquisition |
| What is consolidation (as part of encoding)? | when you create stronger representations over time for info |
| What stage of memory is this? Utilizes stored informations | Retreival |
| A lady can't say the name of objects based on visual input but can with tactile or olfactory input. What does she have? | Visual object agnosia |
| With visual object agnosia, is the region of the brain that stores info about objects intact or not intact? | It is intact but retrieval is impaired when the objects is presented visually |
| People with visual object agnosia have a s_________ retrieval problem. | selective |
| How can we test for STM? | Verbal memory test: digit span test or Spatial memory test; Corsi Block test |
| What are the two types of LTM? | Declarative and Procedural memory |
| What is declarative memory? | Factual information (what you were doing when president died, what your children's names are) |
| What is procedural memory? | ability to do procedures previously learned (tying shoes, swimming) |
| Describe the Digit span test: | A sequence of single digits are presented and participants have to recall it., After correctly recalling each one, a digit is added to the sequence. If the response is wrong the same sequence length is repeated. |
| On average what is people's digit span? | 7 |
| In neurologically healthy patients after what number do the sequences have to be repeatedly shown? | 7 |
| What is the difference between neurologically healthy people and people with amnesic with their digit span? | Those with amnesic have a steeper slope (the require the sequences to be repeated sooner) so have smaller digit span than healthy people |
| Describe the Corsi Block test to test for STM | You are presented with a number of identical blocks and each will be pointed to one at a time in a random order and you have to remember the order in which they were pointed to. If you repeated sequence correctly a block is added |
| What type of amnesia is this? Loss of memories from a period of time before the brain injury | Retrograde amnesia |
| What type of memory is this? Deficit in forming new memories after the brain injury - both STM and LTM | Anterograde amnesia |
| NA gained brain injury from what? | A fencing foil/rod going through his right nostril, upwards toward the left |
| What happened two weeks after NA's rod injury? | He had exploratory surgery causing additional damage |
| What resulted form NA's brain damage? | He got severe memory impairment especially with verbal memory. His intelligence was preserved |
| NA had damage to the __________ bodies | mammiliary |
| There is an anatomical and functional link between the mammillary bodies and what structure? | The hippocampi and so it makes sense that damage to mammillary bodies effects memory |
| What type of memory loss does NA have? | Anterograde amnesia - long term declarative memories |
| is NA still able to perform long procedural memory? | Yes, can still learn new skills |
| When asked to name some contemporary actors NA cannot. He can only name actors from when? | Period before his accident |
| NA also has a couple of years of retrograde amnesia. Is this normal? | Yes |
| So state "spared" or "disrupted" to the following for NA: "Short term memory", Long term procedural memory" and long term declarative memory" | Spared, spared, disrupted (anterograde amnesia and retrograde amnesia for about 2 years) |
| NA's selective impairment for long-term memory in the absence of short-term memory deficits suggests that the neural substrates underlying long-term memory are....? | distinct from those underlying short-term memory |
| NA tells us that STM is subserved by distinct neural pathways or parts of the brain because he has intact _____ but impaired ___ and that the LTM is grouped into declarative and procedural memory because....? | STM, LTM, because he has impaired declarative memory. |
| What are the limitations of interpreting the causes of patient NAs impairments? | Because his damage involved lots of different brain structures so is difficult to know which region of brain damage is specific to memory impairment |
| HM had a surgery to stop epileptic seizures by removing what brain area? | his medial temporal lobes bilaterally (so anterior portion of hippocampus was removed bilaterally) |
| After HM's surgery what did he have? | Severe memory impairments while personality and intelligence was normal |
| Is the posterior portion of HMs hippocampus damaged? | No it is still intact, only the anterior portion was removed |
| Symptoms: given few words to member immediate recall is normal, but after 5 min no memory for being asked, can learn certain tasks, unable to learn new facts or recall new experiences, normal recall of events that occurred at least several years before. ? | Anterograde declarative amnesia |
| So state "spared" or "disrupted" to the following for HM: "Short term memory", Long term procedural memory" and long term declarative memory" | Spared, Spared, Disrupted |
| Patient EE had two seizures. After the second seizure what did neuroimaging reveal? | a tumour in the region of the left temporal-parieto-occipital junction |
| EE underwent surgery to remove the tumour and ended up with what impairment? | Short term memory impairment |
| State whether patient EE's performance on memory tests is spared or disrupted on the following: "digit span", "corsi block span", "long-term memory" | Impaired, normal, normal |
| Patient EE showed impairment in STM specific to....? | verbal material |
| Patient EE's spatial short term memory was normal but his ______ short term memory was not normal. Was his verbal and nonverbal long term memory normal? | verbal, yes |
| What does EE's performance tell us about memory? | That long term and short term memory have distinct neural substrates and that verbal and spatial STM have distinct neural substrates |
| What does HM's performance tell us about memory? | That long term and short term memory have distinct neural substrates and there is distinct declarative and procedural memory |
| Unlike NA what is an advantage of HM;s damage? | HM's damage is restricted to smaller area - medial temporal lobes, bilaterally allowing us to make direct association between his impairments and his damage that we could not make with NA |
| What is the blood supply artery that gives blood supply to the hippocampus? | The posterior cerebral artery |
| So if someone has stroke and then amnesia what blood supply artery has the stroke affected? | posterior cerebral artery |