Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Pharmacology
NSAID's
| Question | Answer |
|---|---|
| enzyme required to produce cascade of events that occur during inflammation | cyclo-oxygenase (COX) |
| synthesized continuously and is present at all times in all tissues and cells | COX 1 |
| synthesized mainly in response to pain and inflammation | COX 2 |
| mainly COX 1 selective NSAIDs | asa, ketoprofen, ansaid, Indocin, feldene, sulindac |
| slightly COX 1 selective NSAIDs | ibuprofen, naproxen, diclofenac |
| slightly COX 2 selective NSAIDs | etodolac (Lodine), Relafen, Mobic (meloxicam) |
| COX 2 selective NSAIDs | Celebrex, vioxx, bextra (both removed from the market d/t increased risk for cardiovascular events |
| more readily absorbed than naproxen and is used when rapid analgesia is desire | naproxen sodium |
| should not be used in pts with chronic alcoholism | tylenol |
| diclofenac produced in combination with cytoprotective agent misoprostol | arthrotec |
| NSAIDs are pregnancy category B | ketoprofen, ibuprofen, diclofenac, indomethacin, medlomen, feldene, sulindac but should be avoided in last trimester |
| NSAIDs that are pregnancy category C | lodine, ansaid, toradol, Relafen, daypro |
| if used in pregnancy, agents that inhibit prostaglandin synthesis may cause | closure of the ductus arteriosus |
| a single dose of Tylenol; 150 mg/kg in children or 7.5-10 grams | may be toxic dose of tylenol |
| dose of Tylenol that is usually fatal | 25 grams |
| obtain a serum Tylenol assay 4 hours after ingestion, if level is > ?, 90% will have hepatic damage | 300mg/m: |
| antidote for Tylenol toxicity | n-acetylcysteine (Mucomyst) |
| if Tylenol is taken in large doses or regularly the store of ? become depleted and may create hepatic necrosis | glutathione, a hepatic conjugate; glucuronidation, the metabolic pathway |
| NSAID that shows no difference in overall safety and efficacy between older and younger patients | Relafen (nambumetone) |
| if pt with RA would benefit from NSAID but are at increased risk for GI effects recommendations for tx are: | low dose prednisone instead of NSAID, nonacetylated salicylate, Celebrex, use NSAID in combo with gastroprotective agent, use low dose aspirin if antiplatelet therapy is indicated |
| acetaminophen max dose | 4 grams |
| Tylenol provides little benefit when ? is the cause of pain | peripheral inflammation |
| nsaids indicated for gout | Indocin, sulindac, ketoprofen |
| max dose of ibuprofen | for mild-moderate pain: 2400mg/day; for oa or ra: 3200mg/day |
| max dose of naprosyn | mild-mod pain: 1250mg/day oa ra: 1500mg/day |
| propionic acid group short acting | ibuprofen, ketoprofen |
| acetic acid group short acting | diclofenac (volatren), indomethacin |
| fenamic acid group short acting | meclofenamate |
| pyrrolizine carboxylic acid group short acting | toradol |
| pyranocarboxylic acid group short acting | etodolac (lodine) |
| propionic acid group intermediate | naproxen, naproxen sodium |
| acetic acid group intermediate | sulindac |
| propionic acid group long-acting | ketoprogen er, oxaprozin (daypro) |
| oxicams long-acting | meloxicam (Mobic), piroxicam (feldene) |
| naphthylalkanone long acting | nabumetone (Relafen) |
Created by:
heatherbrown2020
Popular Pharmacology sets