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Mod 6

Peripheral System Drugs

What are the three main functions of the sympathetic nervous system? 1.Regulation of cardiovascular system. 2.Redistributing blood 3.Compensating for loss of blood
How does the sympathetic nervous system regulate the cardiovascular system? •Maintaining blood flow to the brain •Redistributing blood •Compensating for loss of blood
How does the sympathetic nervous system regulate body temperature? •Regulates blood flow to the skin •Promotes secretion of sweat •Induces piloerection (erection of hair)
How does the sympathetic nervous system implement the "fight-or-flight" reaction? •Increasing heart rate and blood pressure •Shunting blood away from the skin & viscera •Dilating the bronchi •Dilating the pupils •Mobilizing stored energy
What are the general functions of the parasympathetic nervous system? Digestion of food, excretion of waste, control of vision, conservation of energy
What are the specific functions of the parasympathetic nervous system? •Slowing the heart rate •Increasing gastric secretions •Emptying the bladder & bowel •Focusing the eye for near vision •Constricting the pupil •Contracting bronchial smooth muscle
What are the peripheral adrenergic receptor subtypes? Alpha1, Alpha2, Beta1, Beta2, Dopamine
What are the peripheral cholinergic receptor subtypes? NicotinicN, NicotinicM, Muscarinic
What are the peripheral adrenergic receptor subtypes motivated by? Epinephrine
What are the peripheral cholinergic receptor subtypes motivated by? Acetycholine
Where are NicotinicN receptors located? All autonomic nervous system ganglia and the adrenal medulla
Where are NicotinicM receptors located? Neuromuscular junction
Where are Muscarinic receptors located? All parasympathetic target organs - Eye, Heart, Lung, Bladder, GI tract, Sweat, Sex organs & Blood vessels
Where are the Alpha1 receptors located? Eye, Arterioles (skin, viscera, mucous membranes), Veins, Sex organs (male), Prostatic capsule, Bladder
Where are the Alpha2 receptors located? Presynaptic nerve terminals
Where are the Beta1 receptors located? Heart, Kidneys
Where are the Beta2 receptors located? Arterioles (heart, lung, skeletal muscle), Bronchi, Uterus, Liver, Skeletal muscle
Where are the dopamine receptors located? Kidney
NicotinicN: Ganglia & Adrenal medulla.. Function? Stimulation of parasympathetic and sympathetic postganglionic nerves and release of epinephrine from the adrenal medulla.
NicotinicM: Neuromuscular junction.. Function? Contraction of skeletal muscle
Muscarinic: Eye.. Function? - ontraction of the ciliary muscle (focuses lens for near vision) -Contraction of iris sphincter (decreased pupil diameter, MIOSIS)
Muscarinic: Heart.. Function? Decreased rate
Muscarinic: Lung.. Function? -Constriction of bronchi -Promotion of secretions
Muscarinic: Bladder.. Function? -Contraction of detrusor (increases bladder pressure) -Relaxation of trigone & sphincter (allows urine to leave bladder) - Coordinated contraction of detrusor and relaxation of trigone & sphincter (causes voiding of the bladder)
Muscarinic: GI System.. Function? -Salivation -Increased gastric secretions -Increased intestinal tone/motility -Defecation
Muscarinic: Sweat Glands.. Function? Generalized sweating
Muscarinic: Sex Organs.. Function? Erection
Muscarinic: Blood vessels.. Function? Vasodilation
Alpha1: Eye.. Function? Contraction of the radial muscle of the iris (increases pupil size, dilation, MYDRIASIS)
Alpha1: Arterioles: Skin, Viscera, Mucous Membranes.. Function? Constriction
Alpha1: Veins.. Function? Constriction
Alpha1: Sex organs, male.. Function? Ejaculation
Alpha1: Prostatic capsule.. Function? Contraction
Alpha1: Bladder.. Function? Contraction of trigone & sphincter (doesn't allow uring to leave bladder)
Alpha2: Presynaptic nerve terminals.. Function? Inhibition of transmitter release
Beta1: Heart.. Function? Increased rate, force of contraction and AV conduction velocity
Beta1: Kidney.. Function? Release of renin
Beta2: Arterioles (heart, lung, skeletal muscle).. Function? Dilation
Beta2: Bronchi.. Function? Dilation
Beta2.. Skeletal muscle.. Function? Glycogenolysis
Beta2: Uterus.. Function Relaxation
Beta2: Liver.. Function? Glycogenolysis
Dopamine: Kidney Dilates renal blood vessels
Created by: kdanielah



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