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Dose Response

site of drug action, dose response and agonist/antagonists

How do you classify a drug? It is an agent that interacts with specific target molecules in the body and produces a physiological effect
Pharmacodynamics means: The mechanism by which drugs exert their effect on the body for a therapeutic action to occur. Includes drug-receptor interactions
Pharmacokinetics is: what the body does to the drug i.e. absorption, metabolism and excretion
The three main aspects of NON-POTENT drugs are: 1) active at high concentrations 2) little structural specificity 3) cause physical change
The three main aspects of POTENT drugs are: 1) act at low concentrations 2) structural specificity 3) act by chemical interactinon
Receptors are the site at which a ligand attached. They may be: Neurotransmitters, hormones or local factors. Activation of a receptor by these produces a response
with increased concentration of a drug, there is: increased risk of non-specific side effects
Agonists: mimic endogenous ligands, binding to a receptor and causing an effect
Antagonists: bind to a receptor and prevent the action of an agonist. Most are competitive and reersible
Drug-Receptor interaction assumes that: the effect of a drug is proportional to the fraction of receptors occupied
Efficacy is: the measure of a drug's effectiveness to produce a maximal result
Affinity: Binding of a drug to a receptor
Efficacy: Response to binding
ED50 (EC50): 50% of maximal effect
Competitive (surmountable) Antagonism: most common in therapeutic drugs. Maximal effect unchanged. agonist and antagonist compete at high affinity for receptor sites parallel shift to the right
Non-Competitive (Irreversible) Antagonism: receptor must die for effect to stop. act on receptor itself so that agonist can not bind. Max effect no longer produced
Spare receptors
Created by: KitL
 

 



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