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Sulfonylureas

USMLE Step 1

DrugMOA & ADRs
Tolbutamide MOA: + insulin secretion, - K channels, increase intracellular Ca, duration is 8 hrs; ADRs: contraindicated in pts w/ liver or kidney failure, accumulation causes hypoglycemia, tightly bound to albumin
Glyburide MOA: + insulin secretion, - K channels, increase intracellular Ca, duration is 20 hrs (most potent); ADRs: contraindicated in pts w/ liver or kidney failure, accumulation causes hypoglycemia, tightly bound to albumin
Glipizide MOA: + insulin secretion, - K channels, increase intracellular Ca, duration is 20 hrs (most potent); ADRs: contraindicated in pts w/ liver or kidney failure, accumulation causes hypoglycemia, tightly bound to albumin
Chlorpropamide MOA: + insulin secretion, - K channels, increase intracellular Ca, duration is 48 hrs; ADRs: contraindicated in pts w/ liver or kidney failure, accumulation causes hypoglycemia esp this drug, tightly bound to albumin
Created by: jerrica_08
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