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HIV Drugs RUHS

HIV DRUGS

Brand NameGeneric NameDrug ClassAdverse ReactionsPregnancy CategoryDrug InteractionsAbbreviationDosingGeneral Drug Interactions
Videx Didanosine Nukes(Reverse Transcriptase Inhibitor) Pancreatitis, peripheral neuropathy, nausea, vomiting, fatigue, myalgia, bone marrow suppression, mitochondrial dysfunction Tenofovir-Increase AUC but 66-75% dose-60kg-250mg qd, <60kg 200mg qd Additive mito tox with AZT and d4T ddI WT >= 60kg 400 mg qd WT<60kg 250mg qd Renal Dose Adjust
Sustiva Efavirenz Non-Nukes(Reverse Transcriptase Inhibitor) Mental Status Changes(worsens Depression/mania) Dreams-hungover feeling, Manic Feeling, Rash, Drug Interactions, D CYP450-Mixed-St. John's Wort, Midazolam, triazolam, Methadone, Rifabutin, Posaconazole, Voriconazole, Itraconazole, EFV 600 mg qhs
Viramune Nevirapine Non-Nukes(Reverse Transcriptase Inhibitor) Rash, Itching BBW-Liver Toxicity Men- CD4>400Women-CD4>250 CYP450-InducerSt. John's Wort NVP 200 mg bid for 14 days then 400 mg qd
Rescriptor Delaviridine Non-Nukes(Reverse Transcriptase Inhibitor) Liver Dysfunction, Drug Interactions BBW-Liver Toxicity Men-CD4>400, Women-CD4>250 CYP450-Inhibitor St. John's Wort DLV 1200 mg qd
Edurant Rilpivirine Non-Nukes(Reverse Transcriptase Inhibitor) Drug Interactions, Risk for Virologic Failure when VL>100,000, Side effects less than Efavirenz, Rash, Depression, Insomnia, Headache, Can increase resistance in 1st generation NNRTI and Etravirine B St. John's Wort, Antacids-2h before 4h after, h2-12h before, 4h after, PPI-dont use,Carbamazepine, Phenobarbitol, Phenytoin, Dexamethasone Rifabutin RPV 25 mg qd w/meal
Intelence Etravirine 2nd generation Non-Nukes(Reverse Transcriptase Inhibitor) Food Increase Absorption by 50% Works against 1st gen resistant virus, Can cause resistance in all NNRTI's B St. John's Wort, Carbamazepine, Phenobarbitol, Phenytoin ETR 200 mg bid w/meals
Combivir Zidovudine and Lamivudine Combo Nukes(Reverse Transcriptase Inhibitor) Nausea, vomiting, headaches, myalgia, anemia, mitochondrial dysfunction(less when combined with epivir, Pancreatitis, AST/ALT (very well tolerated) Stavudine-require same enzyme don not give together-additive Mito tox with d4T and ddI, Ganciclovir, Interferon, Chemotherapy, 1 T bid (300mg/150mg)Renal Dose Adjust
Epzicom Abacavir and Lamivudine Combo Nukes(Reverse Transcriptase Inhibitor) Hypersensitivity RXN in 8% rash, fever, fatigue, nausea, vomiting, abdominal cramping, respiratory symptoms, Death-hypotension (less frequent in afro-americans)Pancreatitis, AST/ALT (very well tolerated) 1 T qd (600mg/300mg)Renal and Hepatic Dose Adjust
Truvada Tenofovir and Emtricitabine Combo Nukes(Reverse Transcriptase Inhibitor) Minimal(well tolerated) liver, GI, Renal-Hispanics and Afro-Americans, worse with other nephrotoxins, Scr < 50ml/min requires dosing changes, Nausea, Rash, diarrhea, headache, skin discoloration, (very well tolerated) 1 T qd (200mg/300mg)Renal Dose Adjust
Trizivir Abacavir, Lamivudine, and Zidovudine Combo Nukes(Reverse Transcriptase Inhibitor) Hypersensitivity RXN in 8% rash, fever, fatigue, nauseavomitingal crampingrespiratory symptomsDeath-hypotension (less frequent in afro-americans) Pancreatitis, AST/AL headaches, myalgia, anemia, mitochondrial dysfunction(less when combined with epivir) 1 T BID Renal and Hepatic Dose Adjust
Atripla Efavirenz, Tenofovir, and Emtricitabine Combo Nukes(Reverse Transcriptase Inhibitor) Mental Status ChangesworsensDepression/mania Dreams-hungoverfeelingManic FeelingDrug Interactions liverGIRenal-Hispanics and Afro-Americansworse with other nephrotoxins, Scr < 50ml/min requires dosing changesNausea, Rash, diarrhea, headache, skin discolor Renal Dose Adjust
Complera Rilpivirine, Tenofovir, and Emtricitabine Combo Nukes(Reverse Transcriptase Inhibitor) Nausea, Rash, diarrhea, headache, skin discolor liver, GI, Renal-Hispanics and Afro-Americansworse with other nephrotoxins, Scr < 50ml/minrequiredosingchangesDrug Int Risk for VirologicFailurewhen VL>100,000SideeffectslessthanEfavirenzDepression Insomnia Renal Dose Adjust
Stribild Elvitegravir, cobicistat, tenofovir and emtricitabine combo Nukes(Reverse Transcriptase Inhibitor) Integrase Inhibitor Nausea, diarrhea, gas, Increased Scr.1-.2mg/dL-cobicistat effect-.4mg/dL or more renal toxicity CYPdrugintCobicistatCYP450InhibitorAlfuzosinSildenafilforPulHtnCisapridepimozideergotstriazolammidazolamsimvastlovastRifampinStJohnWortCarbamazepinePhenobarbPhenytoinAtorvapitivistatinColchicineFluticasoneDexamethasoneSalmeterolAntiarrythmaAntifungImmunos 1 T qd w/food-Renal Dose Adjust
Fuzeon Enfuvirtide Entry Inhibitor, Fusion Inhibitor Injection site reactions, Injection Fatigue T-20 90 mg bid SUBQ-must be reconstituted and injected-24 hour stability in refrigerator
Selzentry Maraviroc Entry Inhibitor, Co-receptor Antagonist BBW-Hepatotoxicity, Systemic Allergic Reactions, Fever, abdominal Pain, muscle and joint pain. skin rash, cough, upper respiratory tract infection, sleep disturbances B Carbamazepine, Phenobarbitol, Phenytoin-use MCV 600mg bid, Clarithromycin-use MCV 150 mg bid St. John's Wort, Voriconazole, Use MCV 150mg bid, Rifabutin-MCV 300mg bid, Rifampin MCV w/boostedPI Strong 3A inhibitor-150mg bid-with tipraniavir/nrtis/Nevirapine neither inducer or inhibitor, 300mg bid-with efavirenz strong 3A inducer, 600mg bid
Isentress Raltregravir Integrase Inhibitor Good side effect profile, not a cyp450 3A4 problem. Do not use with Rifampin RAL 400 mg T bid no food restrictions, well tolerated
Invirase Saquinavir Protease Inhibitor Can have any but not all-Nausea,diarrhea, gas, bloating, increased serum lipids, increased blood sugar, lipodystrophy, dry skin, increased liver enzymes, osteonecrosis CYPSubstratePhenytoinCarbemazepinePhenobarbitolMonitorSerumlevelsAtorvastatinDecreasedose by50% SildenafilVardenafilTadalafilAUCincreasedDONOTUSEforPul HTNColchicinedoseadjustmentneededFluticasoneadrenalsuppressionMethadoneBoostedPisdecreasemethadonelevel SQV 1000mg/100mg bid SQV/r PI'sDecmet/Incserum-cisapride,pimozide,ergots,triazolam,midazolam,simvast,lovast,pitvas,amiodarone,bepridil, flecainide,propafenone,quinidine,salmeterol,ethinylestridiolIncrease PI met and dec.scr-Rifampin,rifabutin,stJohn'swort,garlicpills
Norvir Ritonavir Protease Inhibitor Can have any but not all-Nausea,diarrhea, gas, bloating, increased serum lipids, increased blood sugar, lipodystrophy, dry skin, increased liver enzymes, osteonecrosis, Vomiting, Drug Interaction, CIRCUMORAL PARASTHESIAS-From Boosting PI's CYP450 SubstrateInhibitorPhenytoinCarbemazepinePhenobarbitolMonitorSerumlevAtorvastatinDecdoseby50%SildenafilVardenafilTadalafilAUCincDONOTUSEforPul HTNColchicinedoseadjustmentneededFluticasoneadrenalsuppressionMethadoneBoostedPisdecreasemethadonelevel RTV 600 mg q12h w/food (capsule 100mg) PI'sDecmet/Incserum-cisapride,pimozide,ergots,triazolam,midazolam,simvast,lovast,pitvas,amiodarone,bepridil,flecainide,propafenone,quinidine,salmeterol,ethinylestridiolIncrease PI met and dec.scr-Rifampin,rifabutin,stJohn'swort,garlicpills
Crixivan Indinavir Protease Inhibitor Can have any but not all-Nausea,diarrhea, gas, bloating, increased serum lipids, increased blood sugar, lipodystrophy, dry skin, increased liver enzymes, osteonecrosis, Nephrolitiasis, Jaundice, Skin changes CYP450 SubstratePhenytoinCarbemazepinePhenobarbitolMonitorSerumlevelsAtorvastatinDecdose by50% SildenafilVardenafilTadalafilAUCincreasedDONOTUSEforPul HTNColchicinedoseadjustmentneededFluticasoneadrenalsuppressionMethadoneBoostedPisdecreasemethadonelevel IDV 800mg po q8h on empty stomach PI'sDecmet/Incserum-cisapride,pimozide,ergots,triazolam,midazolam,simvast,lovast,pitvas,amiodarone,bepridil,flecainide,propafenone,quinidine,salmeterol,ethinylestridiolIncrease PI met and dec.scr-Rifampin,rifabutin,stJohn'swort,garlicpills
Viracept Nelfinavir Protease Inhibitor Can have any but not all-Nausea,diarrhea, gas, bloating, increased serum lipids, increased blood sugar, lipodystrophy, dry skin, increased liver enzymes, osteonecrosis PhenytoinCarbemazepinePhenobarbitolMonitorSerumlevelsAtorvastatinDecreasedose by50% SildenafilVardenafilTadalafilAUCincreasedDONOTUSEforPul HTNColchicinedoseadjustmentneededFluticasoneadrenalsuppressionMethadoneBoostedPisdecreasemethadonelevel NFV 750mg tid or 1250 mg bid PI'sDecmet/Incserum-cisapride,pimozide,ergots,triazolam,midazolam,simvast,lovast,pitvas,amiodarone,bepridil,flecainide,propafenone,quinidine,salmeterol,ethinylestridiolIncrease PI met and dec.scr-Rifampin,rifabutin,stJohn'swort,garlicpills
Lexiva Fosamprenavir Protease Inhibitor Can have any but not all-Nausea,diarrhea, gas, bloating, increased serum lipids, increased blood sugar, lipodystrophy, dry skin, increased liver enzymes, osteonecrosis, RASH-12-19% CYP450 SubstratePhenytoinCarbemazepinePhenobarbitolMonitorSerumlevelsAtorvastatinDecreasedose by50% SildenafilVardenafilTadalafilAUCincreasedDONOTUSEforPul HTNColchicinedoseadjneededFluticasoneadrenalsuppressionMethadoneBoostedPisdecreasemethadonelevel FPV 1400mg bid, 1400mg/200mg qd 700mg/100mg bid FPV/r PI'sDecmet/Incserum-cisapride,pimozide,ergots,triazolam,midazolam,simvast,lovast,pitvas,amiodarone,bepridil,flecainide,propafenone,quinidine,salmeterol,ethinylestridiolIncrease PI met and dec.scr-Rifampin,rifabutin,stJohn'swort,garlicpills
Kaletra Lopinavir and Ritonavir Combo Protease Inhibitor Can have any but not all-Nausea,diarrhea, gas, bloating, increased serum lipids, increased blood sugar, lipodystrophy, dry skin, increased liver enzymes, osteonecrosis CYP450 SubstratePhenytoinCarbemazepinePhenobarbitolMonitorSerumlevelsAtorvastatinDecreasedose by50% SildenafilVardenafilTadalafilAUCincreasedDONOTUSEforPul HTNColchicinedoseadjustmentneededFluticasoneadrenalsuppressionMethadoneBoostedPisdecreasemethadonel LPV/r 2 T bid or 4 qd -200mg/50mg per Tab LPV/r PI'sDecmet/Incserum-cisapride,pimozide,ergots,triazolam,midazolam,simvast,lovast,pitvas,amiodarone,bepridil,flecainide,propafenone,quinidine,salmeterol,ethinylestridiolIncrease PI met and dec.scr-Rifampin,rifabutin,stJohn'swort,garlicpills
Reyataz Atazanavir Protease Inhibitor Can have any but not all-Nausea,diarrhea, gas, bloating, increased serum lipids, increased blood sugar, lipodystrophy, dry skin, increased liver enzymes, osteonecrosis, Hyperbilirubinemia, Jaundice, Not same effect cholesterol and triglycerides other PI's Tenofovir-Dec ATA and AUC levels by 25%, boost with r 100 mg qd ATV 300mg qd CYP450 Substrate-SameasPI's and can't begiven with other PI's. H2-decabsor of ATV, sep by 12h and boost ATV. Antacids Dec Abs ATV antacid 2hs before and 1h after ATV-Raltegravir ATV 400 mg qd 300mg/100mg qd ATV/r PI'sDecmet/Incserum-cisapride,pimozide,ergots,triazolam,midazolam,simvast,lovast,pitvas,amiodarone,bepridil,flecainide,propafenone,quinidine,salmeterol,ethinylestridiolIncrease PI met and dec.scr-Rifampin,rifabutin,stJohn'swort,garlicpills
Aptivus Tipranivir Protease Inhibitor Most difficult PI to take. Can have any but not all-Nausea,diarrhea, gas, bloating, increased serum lipids, increased blood sugar, lipodystrophy, dry skin, increased liver enzymes, osteonecrosis, CNS bleeding, CYP450 Substrate-InducerPhenytoinCarbemazepinePhenobarbitolMonitorSerumlevelsAtorvastatinDecreasedose by50% SildenafilVardenafilTadalafilAUCincreasedDONOTUSEforPul HTNColchicinedoseadjustmentneededFluticasoneadrenalsuppressionMethadoneBoostedPisdecreaseme TPV 2 bid with 2 Norvir-500mg/200mg TPV/r PI'sDecmet/Incserum-cisapride,pimozide,ergots,triazolam,midazolam,simvast,lovast,pitvas,amiodarone,bepridil,flecainide,propafenone,quinidine,salmeterol,ethinylestridiolIncrease PI met and dec.scr-Rifampin,rifabutin,stJohn'swort,garlicpills
Prezista Darunavir Protease Inhibitor Can have any but not all-Nausea,diarrhea, gas, bloating, increased serum lipids, increased blood sugar, lipodystrophy, dry skin, increased liver enzymes, osteonecrosis CYP450 SubstratePhenytoinCarbemazepinePhenobarbitolMonitorSerumlevelsAtorvastatinDecreasedose by50% SildenafilVardenafilTadalafilAUCincreasedDONOTUSEforPul HTNColchicinedoseadjustmentneededFluticasoneadrenalsuppressionMethadoneBoostedPisdecreasemethadonel DRV 2 T bid with Norvir 600mg/100mg DRV/r or 2 T qd with Norvir 800mg/100mg DRV/r (Naive) PI'sDecmet/Incserum-cisapride,pimozide,ergots,triazolam,midazolam,simvast,lovast,pitvas,amiodarone,bepridil,flecainide,propafenone,quinidine,salmeterol,ethinylestridiolIncrease PI met and dec.scr-Rifampin,rifabutin,stJohn'swort,garlicpills
Retrovir Zidovudine Nukes(Reverse Transcriptase Inhibitor) Nausea, vomiting, headaches, myalgia, anemia, mitochondrial dysfunction(less when combined with epivir) Stavudine-require same enzyme don not give together-additive Mito tox with d4T and ddI, Ganciclovir, Interferon, Chemotherapy AZT, ZVD 200 mg tid or 300 mg bid 100 mg 5 times qd Renal Dose Adjust
Zerit Stavudine Nukes(Reverse Transcriptase Inhibitor) Pancreatitis, peripheral neuropathy, nausea, vomiting, fatigue, myalgia, bone marrow suppression, mitochondrial dysfunction Zidovudine-require same enzyme do not give together -additive mito tox with ddI and AZT d4T Wt>= 60 kg 40 mg bid Wt<60 kg 30 mg bid Renal Dose Adjust
Epivir Lamivudine Nukes(Reverse Transcriptase Inhibitor) Pancreatitis, AST/ALT (very well tolerated) 3TC 150 mg bid or 300 mg qd Renal Dose Adjust
Ziagen Abacavir Nukes(Reverse Transcriptase Inhibitor) Hypersensitivity RXN in 8% rash, fever, fatigue, nausea, vomiting, abdominal cramping, respiratory symptoms, Death-hypotension (less frequent in afro-americans) ABC 300 mg bid, 600 mg qd Hepatic Dose Adjust
Emtriva Emtricitabine Nukes(Reverse Transcriptase Inhibitor) Nausea, Rash, diarrhea, headache, skin discoloration, (very well tolerated) FTC 200 mg qd Renal Dose Adjust
Viread Tenofovir Nucleotide reverse transcriptase inhibitor Minimal(well tolerated) liver, GI, Renal-Hispanics and Afro-Americans, worse with other nephrotoxins, Scr < 50ml/min requires dosing changes Increases Didanosine AUC by 66-75%-Atazanavir, Decreases ATA levels and AUC by 25% TDF 300mg qd Renal Dose Adjust
Created by: 1648703985