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OU recptrs/G-protein

matching receptors with G-protein classes

ReceptorG-protein classMajor functions
a1 Gq vascular smooth muscle contraction
a2 Gi decrease sympathetic outflow; decrease insulin release
B1 Gs increase HR, contractility, renin release, lipolysis, aqueous
B2 Gs vasodilation, bronchodilation, glucagon release
M1 Gq CNS
M2 Gi bradycardia
M3 Gq increased exocrine gland secretion
D1 Gs relax renal vascular smooth muscle
D2 Gi modulates transmitter release, esp in brain
H1 Gq nasal & bronchial mucus production, contraction of bronchioles, pruritis, & pain
H2 Gs increased gastric acid secretion
V1 Gq vascular smooth muscle contraction
V2 Gs increased H2O permeability and reabsorption in renal collecting tubules
a1, M1, M3, H1, V1 Gq (blank)
a2, M2, D2 Gi (blank)
B1, B2, D1, H2, V2 Gs (blank)
Created by: PittDave
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