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OU-Newer Seizure Med
Meds
| Drug | Mechanism | Indication | Toxic Potential |
|---|---|---|---|
| Felbamate | blocks glutamate receptors, sodium and calcium channels | Partial seizures, Lennox-Gastaut syndrome, myoclonic | aplastic anemia, acute liver failure |
| Lamotrigine | blocks glutamate receptors and sodium channels | absence or partial seizures | stevens-johnson syndrome, sedation, ataxia, diplopia |
| Topiramate | blocks glutamate receptors | partial seizures | sedation, ataxia, weight loss, word finding difficulty, renal stones |
| Gabapentin | increases GABA effects | neuropathis pain, partial seizures, bipolar, migraine | sedation, ataxia, cognitive change |
| Tiagabine | blocks GABA transporter | partial seizures | sedation, dizziness, flu-like symptoms |
| Vigabatrin | inhibits GABA transaminase | partial seizure | depression, psychosis, visual dysfunction |