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OU autonomic drugs

autonomic drugs, classes, indication

drugclassindication
bethanechol cholinergic agonist (M) ileus, urinary retention
methacholine cholinergic agonist (M & N) Dx--bronchial hyperreactivity
nicotine cholinergic agonist (N) (blank)
pilocarpine cholinergic agonist (M) glaucoma (topical); xerostomia (oral)
edrophonium AChE inhibitor: reversible Dx--myasthenia gravis (t1/2=10min)
physostigmine AChE inhibitor: reversible glaucoma; antidote for atropine OD
neostigmine AChE inhibitor: reversible myasthenia; reversal of nondepolarizing NM blockers
echothiophate AChE inhibitor: irreversible organophosphate
malathion AChE inhibitor: irreversible organophoshate
parathion AChE inhibitor: irreversible organophosphate
tacrine AChE inhibitor Alzheimer's (CNS entry)
donezipil AChE inhibitor: reversible Alzheimer's (CNS entry)
atropine M blocker antispasmodic, antisecretory, antidiarrheal, mgmt of AChE inhibitor OD
tropicamide M blocker ophthamology (topical)
ipratroprium M blocker asthma, COPD (inhalational)--no CNS entry or change in mucus viscosity
scopolamine M blocker motion sickness, causes sedation and short-term memory block
glycopyrrolate M blocker antispasmodic, antisecretory, antiulcer--no CNS entry
benzotropine M blocker parkinsonism, drug-induced EPS--CNS entry
trihexyphenidyl M blocker parkinsonism, drug-induced EPS--CNS entry
hexamethonium NN (ganglion) blocker prototype, with no clinical use
mecamylamine NN (ganlion) blocker severe HTN, for controlled hypotension during surgery, smoking cessation, Tourette's
Created by: PittDave
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