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Anti-Emetics

USMLE Step 1

DrugMOA & ADRs
2 Brainstem areas associated w/ vomiting 1)chemoreceptor trigger zone in area postrema[CVO ventral to 4th ventricle]outside BBB-can re directly 2 chem +;2)vomiting ctr in lateral reticular formation of medulla coordinate motor mechanism of vomit & re 2 afferent input from vestibula,periphery,etc
Meclizine MOA: H1 blocker,used for vertigo
Metoclopramide MOA: DA receptor antagonist used for nausea associated w/ chemotx, @ high doses highly effective vs highly emetic cisplatin drug; ADRs: anti-DA side effects that limits use @ high doses leading to Parkinsonian-like effects
Droperidol MOA: DA receptor antagonist used for nausea & emesis due to radiation tx
Created by: jerrica_08
Popular Pharmacology sets

 

 



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