Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.

Remove ads
Don't know
Know
remaining cards
Save
0:01
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards




share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

anti-inflammatory

NSAIDs and glucocorticoids

QuestionAnswer
Abnormal Immune Responses? 1. Extensive tissue damage (Hypersensitivity) 2. Reactivity against self its own cells and tissues(antoimmunity) *炎症: 自身免疫系統過敏,攻擊自身
Pharmacological Actions of NSAIDs 1. Anti-inflammatory - reduce vasodilation and vascular permeability - reduce edema, swelling and redness 2. Analgesic - reduce sensitization of pain nerve endings 3. Antipyretic - reduce set-point of hypothalamic themoregulatory center
Side-effects of normal NSAIDs [ both cox-1 and cox-2 inhibitors) 1. GI (GI disorder) 2. Platelets (prolonged bleeding,aspirin:anti-platelet) 3. Kidneys (nephropahty 腎痛)
Mechanism of NSAIDs inhibit cyclooxygenase 1 and 2 -> COX catalyzes the formation of Eicosanoids e.g. prostaglandins and thromboxane from arachidonic acid (derived from phospholipid bilayer by phospholipase) -> Prostaglandins as messenger molecules in inflammation
why selective cox-2 inhibitors of NSAIDs better? e.g.? disadvantage? e.g. celecoxib [coxb] selective COX-2 inhibitor x cause gastric problems,less effect on platelet i.e. cox-2 is inducible which only act on the inflammatory sites, cox-1 is constitutive 固有的 (保護GI,platelet) Bad: renal deficiency 腎虧,thrombosis (coagulatio
Aspirin NSAID : salicylates cox-1 selective salicylates 水楊酸 mainly for anti-platelet drug cox-2 is inducible which only act on the inflammatory sites, cox-1 is constitutive 固有的 (保護GI ,platelet).
Ibuprofen NSAID : propionic acid more selective to cox-2 inhibitors
Diflunisal NSAID : salicylates more selective to cox-2 inhibitors no antipyretic effects
Paracetamol / Acetaminophen weak cox-1 n cox-2 inhibitor NOT NSAID! non-opiod anaglestic lack of anti-inflammatory effect! anaglesic effect + antipyretic SE: hepatotoxity if 8 x 500mg in a day anti-dose: Fluimucil
Pharmacological Actions of Glucocorticoids 糖大白咬前列腺 1. cause vasoconstriction [大]and reduce capillary permeability 2. inhibit white cell [白]adhersion with endothelial cells 3.inhibit the function of macrophages [咬]and other APCs (reduce phagocytosis and T cell activation ) 4. Inhibit production of prost
Hydrocortisone its pro-drug? Gp: Glucocorticoids For: anti-inflammation (short acting) Pro-drug (inactive): cortisone converting enzyme: 11(B)-HSD1
Prednisolone its pro-drug? Gp: Glucocorticoids For: anti-inflammation (short acting) Pro-drug (inactive): Prednisone converting enzyme: 11(B)-HSD1
Dexamethasone 爹曬米花嫂 Gp: Glucocorticoids For: anti-inflammation (long acting)
Betamethasone 病態米花嫂 Gp: Glucocorticoids For: anti-inflammation (long acting)
Side effect of Steroids 1 . insomnia 2. peptic ulcer 3. fat gian 4. muscle wasting 5. osteoporosis 6. poor wound healing
Withdrawal of Steroids *step down before withdrawal * nd 2-12 ms for recovery of adrenal function anohter 6-9 ms for recovery of steroids lv or else -> cause adrenal insufficiency 腎虧 - hypoglycaemia (自己唔識出glucocorticoids => iatrogenic 醫源性的Addison's disease) -> circulatory
Created by: kopoyeehk