Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Bowie's Antibiotics
| Antibiotics | M | For: | SE |
|---|---|---|---|
| Penicillin | Bactericidal M: inhibit bacterial cell wall synthesis ( bind to PBPs -> cross link weaken + death) | / | / |
| Beta-lactamase inhibitor | e.g. Clavulanic acid , tazobatam M: inhibit inhibitor inversely | For: protect beta-lactamase sensitive penicillin from enzymatic inhibition Augmentin = amoxicillin + clavulanic acid Timentin = Ticarcillin + clavulanic acid Tazocin = Piperacillin + Tazobactam | / |
| Tetracyclines 四環素 | Bacteriostatic (Board spectrum) e.g. Doxylcycline M: inhinbit protein synthesis by inhiting 30S of ribosome **: Al / Ca / Mg anatacids reduce absorpotion of oral tetracyclines ** Fe/ bismuth subsalicylate, ZnSO4 ** milk/ milk produce reduce absorpt | Boared range | 1. damage to liver and kidney 2. permanent discolouration of teeth 3. photosensitization (曬太陽位會rash) **: Al / Ca / Mg anatacids reduce absorpotion of oral tetracyclines ** Fe/ bismuth subsalicylate, ZnSO4 ** milk/ milk produce reduce absorption |
| Cephalosporins (Cef- / Ceph-) | e.g. Cefuroxime = Zinacef / Zinnat beta-lactamase sensitive M: inhibit bacterial cell wall synthesis ( bind to PBPs -> cross link weaken + death) | / | / |
| Carbapenems (-penem) | e.g. meropenem, Tienam = Imipenem + Cilastatin (protect from acid degration] | / | / |
| Macrolides [-thromycin] | e.g. Erythromycin, Clarithromycin Bacteriostatic M: inhibit 50S ribosime | penicillin substitute for allergic patients URI / LRI Genial chlamydial infection | Safe Erythromycin : hepatitis |
| Clindamycin | Bacteriostatic inhibit 50S ribosome | Rare infection by Bacteroides fragilis | Fatal Pseudomembranous colitis (by CD)偽膜性大腸炎 |
| Vancomycin | Bactericidal G: Glycopeptides M:inhibit cell wall synthesis | Enterocolitis with CD | Red man syndrome (if fast IV) |
| Fluroquinones [-floxacin] | Bactericidal M:inhibit DNA replication | URI/LRI/ UTI | Safe. photosensitivity, ruptured tendons!! |
| Metronidazole | Flagyl M:inhibit DNA replication | anaerobic infections Protozoal infections | Diarrhea |
| Sulphonamides | Bacteriostatic e.g. SMZ M: inhibit synthesis of folic acid | board range | Drug resistance |
| Trimethoprim | Bacteriostatic M: inhibit synthesis of folic acid | / | Folic acid deficiency e.g. anemia, leukopenia & graunlocytopenia |
| Cotrimoxazole | = trimethoprim + sulphamethoxazole | synergistic bactericidal effect | hypersensitivity |
| Chloramphenol | Bacteriostatic inhibit 50S ribosome | / | Grey baby syndrome |
| Aminoglycoside 安甘糖 [ -mycin] e.g. Amikacin, Getamycin, Streptomycin | Bactericidal e.g. Streptomycin,Gentamycin,amikacin M: inhibit protein synthesis by inhibiting 30S subunit ribosome | -ve aerobic bacilli ^ effect with: 1. Penicillin ( 佢inhinit cell wall , 幫穿牆) 2. Neuromuscular blocker ( increase NM blockade -> muscle relex + respiratory suppress) | SE: damage to ear + damage to kidney + NM blockage |
| Name 4 groups of Penicillin | 1. beta-lactamase-sensitive penicillins 2. beta-lactamase-resistent penicillins 3. Extended spectrum aminopenicillins 4. Extened spectrum antipseudomonal penicillins e.g. in next page | 1. Penicillin G (Benzylpenicillin) , Penicillin V (Phenoxybenzylpenicillin) [Long acting: Benzathine Penicillin G] 2. Cloxacillin 3. Amoxiciliin , Ampicillin 4. Ticarcillin, Pipercillin | 1. Benzathine Penicillin G (IM) 2. bukly chain block beta-lactamase 3. acid stable (PO) 4. for pseudomonas aeraginses |
Created by:
kopoyeehk
Popular Pharmacology sets