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Antihistamines

USMLE Step 1

DrugMOA & ADRs
Diphenhydramine aka Benadryl MOA:H1 receptor blocker,good local anesthetic,prevents sxs of motion sickness,indications include allergy & motion sickness;ADRs:sedation (can be used to tx insomnia),tinnitus,fatigue,dizzinesss,blurred vision,antiCh effects,dont take w/ MAOIs
Chlorpheniramine MOA:H1 receptor antagonist,1st generation antihistamine;ADRs:sedation,tinnitus,fatigue,dizzinesss,blurred vision,antiCh effects,dont take w/ MAOIs
Hydroxyzine MOA:H1 receptor antagonist,1st generation antihistamine;ADRs:sedation,tinnitus,fatigue,dizzinesss,blurred vision,antiCh effects,dont take w/ MAOIs
Desloratadine MOA:2nd generation antihistamine,non-sedating b/c cross BBB less readily;ADRs:sedation,tinnitus,fatigue,dizzinesss,blurred vision,antiCh effects,dont take w/ MAOIs,predispose to arrhythmia (Torsade de Pointe) used w/ macrolide,ketoconazole & itraconazol
Fexofenadine aka Allegra MOA:2nd generation antihistamine,non-sedating b/c cross BBB less readily;ADRs:sedation,tinnitus,fatigue,dizzinesss,blurred vision,antiCh effects,dont take w/ MAOIs,predispose to arrhythmia (Torsade de Pointe) used w/ macrolide,ketoconazole & itraconazol
Created by: jerrica_08
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