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Hallucinogens

USMLE Step 1

DrugMOA & ADRs
Lysergic Acid Diethylamide (LSD) MOA:5-HT agonist in midbrain = + SNS cause arousal,tachy,sweating,mydriasis,high BP,piloerection,fever,@ low dose color hallucinations & mood alterations, high dose = schizophreniform psychosis long term;ADRs:hyperreflex,nausea,muscle weakness
Tetrahydrocannabinol (THC), therapeutically known as dronabinol MOA:alkaloid in marijuana,prod euphoria,drowsiness,relaxation depend on situation,increase appetite,xerostomia,visual hallucinations,delusions,used clinically 4 severe emesis in chemo & +hunger;ADRs:red conjunctiva,increased HR,decreased BP,- motor skills
Phencyclidine (angel dust) MOA - reuptake of DA,5-HT,NE,strong antiCh activity,mood elevation,sense of intox,increased sensitivity 2 external stimuli = bizarre & aggressive behavior 4 up 2 a wk
Phencyclidine (angel dust) ADRs hypersalivation,dissociative anesthesia,numbness of extremities,staggered gait,slurred speech,muscle rigidity,@ high doses full anesthesia,stupor or coma-eyes remain open throughout, tolerance if used on a chronic basis
Created by: jerrica_08
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