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Rang and dale H6

fenylefrine adrenerge α1 R agonist (bij stimulatie: contractie gladde spiercellen UITZ: GIS) ° oog mydriasis: pupilverwijding, GEEN cycloplegie (= voordeel op anticholinergica) ° decongestie neus
oxymetazoline ° Decongestie neusslijmvlies ° Neusdruppels of spray ° ɑ-mimetica induceren vasoconstrictie, daardoor secretie ↓
clonidine Selectieve agonist van ɑ2 R in CZS, stimulatie geeft vasodilatatie,zie blz 65. α2 R: constrictie/dilatatie Vasodilatatie: in CZS, inhibitie O.S. output-> Vasodilatie-> BP daling. Vasoconstrictie: Endotheelcel/gsc, circulerend A, -> vasoconstrictie.
dobutamine ° selectieve β1 agonist, iv, contractiliteit ↑ ° Nevenwerkingen: aritmieën ° Vaak in combinatie met dopamine gegeven (VD in nieren, renale perfusie ↑en GFR ↑)
salbutamol ° Tegen astma ° Via inhalatie ° Selectieve β2 agonist ° Nevenwerking: systemisch (toch prikkeling β1) + tachycardie, aritmieën, tremor en vasodilatatie
prazosine ° Selectieve ɑ1- antagonist ° Toepassing: hypertensie, minder reflex tachycardie ° Nevenwerking: orthostatische hypertensie
atenolol Selectieve β1-antagonist
Adrenaline ° Bij acute anafylactische reactie (Im, acuut) ° Bij hartstilstand (iv) ° ɑ/β agonist (met iets meer affiniteit voor β dan voor ɑ) ° toevoeging van een vasoconstrictor zoals adrenaline bij lokale anesthesie vertraagt de resorptie van lokale anesthetica
Noradrenaline ɑ-agonist (met lichte affiniteit voor β)
Isoprenaline Β-agonist
Ergotamine ° Inhibeert vasoconstrictie van NA (bezet ɑ1- R) ° Partiële agonist 5-HT 1D: VC ° Toepassing: Migraine
Propranolol Β-antagonist (β1 en 2)
Pindolol ° ↑ hartfrequentie (bij rust) maar onderdrukt de tachycardie veroorzaakt door sympathische stimulatie. ° Partiële β-agonist = β-blokker met intrinsieke sympathicomimetische activiteit
Atenolol Selectieve β1-antagonist
Amfetamine ° Indirect sympaticomimetica (verdringen NA uit vesikels) ° Perifeer effect: BD ↑, tachycardie, bronchodilatatie, ↓motiliteit GIS ° Centraal effect: euforie, alertheid ↑, eetlust remmend, schizofreenachtig syndroom
Efedrine indirecte sumpathicomimetica: Mao inhibitor ->> Hypertensie. Zie lijst verder
Tyramine indirecte sumpathicomimetica: Mao inhibitor ->> Hypertensie. Zie lijst verder.
cocaine ° Remmer neuronale opname (uptake 1) ° Tachycardie en toename in BP
tricylische antidepressiva (desipramine) ° Remmer neuronale (NA) opname (uptake 1) ° Centrale effecten + perifere effecten: tachycardie en arithmieën = tricyclisch antidepressiva
Created by: 100000194061121



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