Save
Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't know
Remaining cards (0)
Know
0:00
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Cholinergic Drugs

USMLE Step 1

DrugMOA & ADRs
Nicotinic (ligand gated ion channels), SNS & PNS ganglia-Type 1 sites, skeletal muscle-Type 2 sites
Muscarinic M1: ANS ganglia, brain, gastric parietal, vascular smooth muscle, M2: heart, M3: glands & bronchial smooth muscle, M4: CNS, M5: CNS; M1, 3, & 5 + PLC = Ca influx; M2 & 4 - adenylate cyclase = K out & Na in
Bethanechol MOA: direct cholinergic used for atonic bladder, i.e. postpartum to increase bladder tonicity; ADRs: diaphoresis, flushing, increased urinary urgency, nausea & diarrhea
Pilocarpine MOA: direct cholinergic used via eyedrops for acute angle glaucoma, decreases accommodation, most potent + of glandular secretion if used systemically; ADRs: diaphoresis, flushing, increased urinary urgency, nausea & diarrhea
Carbachol MOA: direct cholinergic only used via eyedrops for glaucoma, very long duration w/ very high potency; ADRs: diaphoresis, flushing, increased urinary urgency, nausea & diarrhea
Physostigmine MOA: AChEI used in the tx of myasthenia gravis, increased GI & bladder motility, also used to tx overdose w/ TCAs & atropine
Neostigmine MOA: AChEI used in the tx of myasthenia gravis, increased GI & bladder motility; ADRs: spastic paralysis
Edrophonium MOA: AChEI shorter onset & duration of action than neostigmine, used to dx myasthenia gravis that will give relief of sxs; ADRs: cholinergic crisis; *Note antidote is atropine*
Organophosphates MOA: AChEI used in the tx of closed angle glaucoma due to strong miotic effect, otherwise used for insecticides & nerve gas; *Note antidote is atropine or pralidoxime (2-PAM)*
Atropine MOA: antimuscarinic, a belladonna alkaloid, works centrally & peripherally, use 4 reverse bradycardia & reduce hyperactive bladder, incurs mydriasis-inability focus 4 near vision
Scopolamine MOA: antimuscarinic drug that is a belladonna alkaloid, >er CNS effect than peripheral effect, duration is >er than that w/ atropine, most effective 4 motion sickness; ADRs: block short term memory, low dose include sedation, high dose causes excitement
Atropine ADRs urinary retention, xerostomia, blurred vision, 'sandy' eyes, tachycardia, constipation, confusion & glaucoma attack
Tubocurarine MOA: antinicotinic, nondepolarizing, competitive blocker, affects the small, rapid muscles 1st, then lrger ones & finally the diaphragm; *Note antidote neostigmine or edrophonium depend on degree of overdose &/or sxs*
Pancuronium MOA: antinicotinic, nondepolarizing drug causes less histamine release than tubocurarine-so more favorable side effect profile; ADRs: vagolysis w/ resultant dangerous tachycardia
Succinylcholine MOA: antinicotinic, depolarizing blocker acts like ACh binding @ receptors-persists there, initial cause fasciculations then flaccid paralysis, use 4 rapid endotracheal intubation, electroconvulsive shock tx & surgery
Succinylcholine ADRs significant apnea, malignany hyperthermia if used in combination w/ anesthetic agent called halothane (occurs in genetically susceptible ppl) & tx is dantrolene that - Ca release from sarcoplasmic reticulum
Antinicotinic drugs ADRs note that exercise caution when using drugs such as halothane, aminoglycosides (- ACh release) & Ca channel blockers that enhance neuromuscular block
Created by: jerrica_08
 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards