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Anti-Coagulants

USMLE Step 1

DrugMOA & ADRs
Heparin MOA: enhances activity of antithrombin 3 (inactivates thrombin-2, factor 13, 9, 10, 11 & 12), used for PE, DVT, MI & those on dialysis, monitor tx by looking @ the aPPT (partial thromboplastin time) in the intrinsic pathway, *Antidote = protamine sulfate*
Dalteparin MOA: - primarily factor 10; ADRs: effects cant be readily or rapidly reversed, no antidote
Enoxaparin MOA: - primarily factor 10; ADRs: effects cant be readily or rapidly reversed, no antidote
Tinzaparin MOA: - primarily factor 10; ADRs: effects cant be readily or rapidly reversed, no antidote
Warfarin MOA: antagonist of Vit K (- factors 2, 7, 9, 10), monitor tx by looking at the PT in the extrinsic pathway, *Note antidote is Vit K*; ADRs: 99% bound to albumin, easily displaced from albumin, hemorrhage, contraindicated in pregnancy b/c crosses placenta
Dicumarol MOA: antagonist of Vit K (- factors 2, 7, 9, 10), *Note antidote is Vit K*; ADRs: 99% bound to albumin, easily displaced from albumin, hemorrhage, contraindicated in pregnancy b/c crosses placenta
Created by: jerrica_08
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