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Thrombolytics

USMLE Step 1

DrugMOA & ADRs
Streptokinase MOA: + plasminogen (plasmin then degrades fibrin) & also catalyzes degradation of fibrinogen & factors 5 & 7, derived from streptococci; *Note antagonist is aminocaproic acid*
Urokinase MOA: works to degrade fibrin by + plasminogen, less antigenic than streptokinase b/c its derived from human fetal renal cells rather than bacteria
Tissue type Plasminogen Activator (tPA aka alteplase) MOA: 'fibrin selective,' so only + plasmin that is already bound to fibrin, thus targets only those areas that have already begun to form clots = allows for targeted tx w/o many complications, very effective for MI, PE & acute ischemic stroke
Created by: jerrica_08
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