click below
click below
Normal Size Small Size show me how
Stack #127004
clindamycin, metronidazole, ampicillins, amoxicillin
Question | Answer |
---|---|
Ampicillin-spectrum | gram + cocci (Haemophilus influenzae) and entococci (E. coli & Salmonella); used alone or w/ probenecid for gonococcal infections |
Amoxicillin:why preferred | produces higher blood levels, better absorbed, less frequent dosing, drug of choice premed |
Amoxicillin-spectrum | upper resp tract infections (H. influenzae), UTI (E.coli) meningitis (H.influenzae), Otitis media in children |
ampicillin | most likely to produce a rash of all pcn's, more common in people w/ mono, seen in patients taking allopurinol. |
carbenecillin | wider spectrum of action than pcn g; special activity against P. aeruginosa: gram- anaerobic rod (blood, lung or burn infections) and some strains of Proteus (g- flagellated bacillae) and E.coli |
carbenecillin | TREATS SYSTEMIC INFECTIONS |
Clindamycin spectrum | very active against several anaerobes, g+ mo's and anaerobic Bacteriodes species |
clindamycin | can cause pseudomembranous colitis |
clindamycin moa | interferes with bacterial cell wall synthesis |
clindamycin | Bacterial resistance acts in a slower manner. Occuring by mutations in the bacterial ribosomes that decrease in the binding capacity of the drug. |
cross resistance | between clindamycin and erythromycin is often seen-they are antagonists |
clindamycin:adverse effects | GI, pseudomembranous colitis, suprainfection of candida albicans, oral allergic reatctions include GLOSSITIS and STOMATITIS (oral mucosa inflammation) edema and serum sickness |
metronidazole aka | Flagyl |
metronidazole: spectrum | BACTERIOCIDAL: action against most anaerobes ie. Bacterioides, fusobacterium, veillonella, treponema, clostridium, peptococcus, campyloacter adn peptostreptococcus: includes protozoa Tricomonas vaginalis and E. Histolytica |
metronidazole: moa | cytotoxic to bacterial cells, freely enters cells and prevents DNA synthesis leading to death of mo. Also has some antiinflammatory effects |
metronidazole: pharmacokinetics | well absorbed orally, somewhat concentrated in gingival crevicular fluid, producing concentrations that are bacteriocidal for periodontal pathogens |
metronidazole: distribution | saliva, spinal fluid, and breast milk in concentrations approximating that of the serum |
metronidazole: oral effects | xerostomia, metallic taste, altered taste of alcohol (sometimes used to treat alcoholics) glossitis, stomitis, black furred tongue |
metronizole: drug interactions | alcohol, phenobarbital and phenytoin (Dilantin) |
metronidazole: uses dental | many perio infections b/c of anaerobic efficacy NO ACTION AGAINST AA: combo w/ amoxicillin to treat juvenile and refractory perio |