Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Didn't know it?
click below
Knew it?
click below
Don't know
Remaining cards (0)
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Digoxin PK

Pharmacokinetics of Digoxin for final exam

Therapeutic range 0.7-2 ng/mL (narrow!)
How long does it generally take for VENTRICULAR RATE CONTROL? Usually achieved by 24 hours
How is loading dose given & why? Loading dose is DIVIDED due to a LONG DISTRIBUTION T1/2
___( Higher / Lower )___ doses are used in the ACUTE SETTING to control rate (>2ng/mL) HIGHER
(T/F) Dose is proportional to [serum] as well as many disease states FALSE! Dose & [serum] are POORLY CORRELATED (as well as renal impairment, drug intxns, age, thyroid DZ, & hypokalemia)
(T/F) Levels are determined by clinically measurable endpoints FALSE! There are no readily measurable clinical endpoints for dig
Name 3 DZ-states that might cause std doses to produce toxic fx. Renal insufficiency, hypokalemia, hyper/hypothyroidism
What Sx might a patient show that would cause you to suspect toxicity (6)? * Anorexia - N/V - Confusion - visual disturbances - arrhythmia - confusion in elderly
What is the Volume of distribution for dig in normal patients vs patients with renal dysfxn? Normal = ~7 L/kg (range: 5-10) Renal Dysfxn =(decreased ) 4-5 L/kg
What factors would caused the volume of distribution to decrease? (3) Renal insufficiency, age, exercise
V & CL are calculated based on ____________________. Renal function
How much is renally excreted in urine (unchanged)? 60-80%
Name 8 important drug interactions with dig. - Spironolactone - Amiloride - Nifedipine - Verapamil - Rifampin - Quinidine - Diazepam - Amiodarone
Which drugs increase dig levels (6) & by what mechanism? Primarily by MDR1 aka PgP/ABCB1 inhibition: - amiodarone, quinidine, ditiazem, nifedipine, verapamil, & spiro
Created by: myassen



Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards