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Epilepsy drugs

QuestionAnswer
The following drugs are first-line for tonic-clonic seizures, EXCEPT: A) Carbamazepine; B) Diazepam; C) Phenytoin; D) Valproic acid B) Diazepam. Benzodiazepenes are first-line for acute status epilepticus and may be used for the seizures of eclampsia (first-line is MgSO4).
Which drug is first-line for absence seizures? A) Carbamazepine; B) Ethosuximide; C) Felbamate; D) Phenytoin; E) Valproic acid B) Ethosuximide. Valproic acid may also be used, but it is not first-line.
To prevent absence seizures, you would most likely use a drug with which mechanism? A) Antagonize NMDA receptors; B) Inactivate voltage-gated Na+ channels; C) Inhibit GABA reuptake; D) Inhibit T-type Ca2+ channels; E) Modulate GABA release D) Inhibit T-type Ca2+ channels. Ethosuximide has been proposed to have this mechanism in the thalamus. It seems that we are responsible for knowing this, even though there seems to be some controversy regarding whether or not this is really true.
Which drug is first-line for a patient with trigeminal neuralgia and a history of tonic-clonic seizures? A) Carbamazepine; B) Gabapentin; C) Lamotrigine; D) Phenytoin; E) Valproic acid A) Carbamazepine. This drug stabilizes the inactive state of Na+ channels.
The first-line drug for partial seizures has which mechanism of action? A) Blocks Ca2+ channels; B) Blocks NMDA channels; C) Increases Na+ channel inactivation; D) Inhibits AMPA receptors; E) Inhibits GABA reuptake C) Increases Na+ channel inactivation. This drug is carbamazepine, and is also first-line for trigeminal neuralgia, as well as one of the first-line drugs for tonic-clonic seizures (along with phenytoin and valproic acid).
Created by: kesselmb