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C/P Test 3
CP Exam 3- Spring 13
Question | Answer |
---|---|
What is the name given to Phase 1? | Acute Phase |
At what location does it take place? | Hospital Setting |
How many days does it last? | 3-5 days |
Phase I Goals | Get out of bed, ADL, UE/LE ex's, Supervised ambulation |
Time/Session | 20-30 mins |
Frequency per day | 2-3x/day |
Intensity Level | 2-3 METs |
Progression of time/frequency/intensity | 30-45 minutes, 1-2x/day, 3-5 METs |
Phase I RPE? | Light |
Phase I HR restrictions | Never increase 10-20 bpm from rest |
HEP: ambulation time & frequency | 20-30 min, 1-2x/day, 4-6x/week |
HEP: UE & LE | ROM, Flexion/Extension |
Phase 2 is called? | Sub-Acute phase |
Most payers allow for how many visits? | 36, usually 3x/week for 12 weeks |
Phase 2 time of exercise | 30-60 in with 5-10 min warm-up & cool-down |
What MET for exit point? | 9 METs |
When to begin strength training for phase 2? | 3 week in cardiac rehab; 5 wk post-MI; 8 wk post-CABG |
Where do phase 3 activities occur? | Community center, YMCA, Clinical facilities |
Phase 3 entry level criteria | Functional capacity of 5 METs; Clinically stable angina; Medically controlled arrhythmias during exercise |
Phase 3 progression | 50-85% functional capacity; 3-4x/week; 45 minutes or more |
Phase 3 D/C | 6-12 months |
2 Main functions of the conducting zone? | Warming & Humidifying inspired air; Filtration & Cleaning of inspired air |
Functions of Ciliated Cells? | Propel mucus blanket up to opening b/t larynx & pharynx where mucus content can either be coughed up or swallowed |
Functions of clara cells? | Synthesize & secrete proteins ("antibodies" & lysosymes to detox harmful substances); Differentiate into ciliated cells to regenerate bronchiolar epithelium |
Functions of basal cells? | Thought to be bronchial stem cells & can differentiate into either clara cells or ciliated cells |
Functions of goblet cells? | Mucus from goblet cells mix with other secretions of mucus blanket that serves to trap small particles in the inspired air & thereby performs a filtration function |
Functions of submucosal glands? | Secrete mucins, antimicrobial substances, & copious amounts of fluid that add to the liquid that composes the mucociliary blanket |
4 components of respiratory zone? | Respiratory bronchioles; Alveolar ducts; Alveoli sacs; Alveoli |
2 serous membrane layers that surround the lungs? "Space" b/t membranes? | Parietal Pleura- lines inside of thoracic wall & covers diaphragm; Visceral Pleura; surface of the lungs; Pleural cavity is between 2 layers |
At the end of expiration what is the net mvmt of air & why? | No net mvmt at end of expiration b/c there's no difference in pressure b/t atmospheric pressure & intrapulmonary pressure |
During inspiration what is the net mvmt of air & why? | Air into the airways b/c decrease in intrapleural pressure causes a decrease in intrapulmonary pressure, causing negative pressure difference b/t atmospheric pressure & intrapulmonary pressure |
At the end of inspiration what is the net mvmt of air & why? | No net mvmt at end of inspiration b/c atmospheric pressure & intrapulmonary pressure equalizes |
During expiration what is net mvmt of air mvmt of air & why? | Chest cavity returns to resting position (inward & down) & diaphragm returns to bell shape position; This creates + pressure difference causing air to move out of airways |
Lung Compliance | Ease at which the lung can be expanded during inspiration |
Lung Elasticity | Ease at which the lung can return or "recoil" back to the resting state |
What controls the resistance to air flow through the conducting system? | The radius of the airways |
What controls surface tension? | Thin film of surfactant containing fluid that lines the components of the respiratory zone |
Compliance of lungs if a drop of 6 mmHg in intrapleural pressure results in mvmt of 400 mL of air into lungs? | 400/6 = 66.7 |
Compare ease at which lung A & lung B expand if A has compliance=100 & B has compliance=80 | Lower compliance=harder to inspire air; Lung B has lower compliance so it takes more work to bring air into lung B |
What components within the lungs provide the ability for the lungs to return to their initial size after being distended during inspiration? | High content of elastic fibers & elastin proteins within the septa or walls of the lung provide elastic recoil that enables lungs to return to resting position after inspiration |
Alveolus A & B have a surface tension of 50, but A has a radius of 1 & B a radius of 1.5. Using Laplace formula what is pressure in each alveoli? | A = 2 x 50/1 = 100/1 = 100; B = 2 x 50/1.5 = 100/1.5 = 66.7 |
If both lungs were connected which one would expand & which would collapse? | Air flows from high pressure to low pressure; therefore, air would flow from alveolus A to alveolus B, thus alveolus A would collapse |
Taken by themselves, which one would be easier to expand (ie need least pressure to expand)? | Smaller the radius of the alveolus, the more pressure it takes to expand the sphere; therefore, alveolus A would be harder to expand |
How does surfactant reduce surface tension? | Surfactant "fits" in b/t water molecules, reducing surface tension; Higher concentration of surfactant, lower surface tension |
Alv. C & D are situated in healthy lung & have normal surfactant. If C has radius 1 & D radius 2, which one has the greatest concentration of surfactant molecules per unit of surface area in order to prevent one collapsing into the other? | The smaller the radius of an alveoli the higher the concentration of surfactant. Therefore, Alveolus C would have the higher concentration of surfactant. |
Why do premature babies have a high risk for respiratory distress syndrome? | Failure of type II alveolar cells to produce sufficient levels of surfactant (type II alveolar cells aren't "mature") |
Tidal Volume (Vt) | Volume of air moved into & out of the lungs during quiet breathing |
Vital Capacity (VC) | Volume of air equal to toal lung capacity minus residual volume (TLC-RV) |
Total Lung Capacity (TLC) | Volume in the lungs at max inflation |
Residual Volume (RV) | Volume of air remaining in lungs after a max exhalation (can't be measured by spirometry) |
A= FVC 5 L & FEV1 3 L; B= FVC 4 L & FEV1 3 L What are FEV1/FVC ratios? Which likely smokes cigarettes? | A ratio - 3/5 = .6 B ratio - 3/4 = .75 Healthy adult ratio should be 75-80%, so person A probably smokes |
Given the following locations in the lungs, which would have the highest PO2 & which would have the lowest: trachea, bronchi, alveoli? Why? | Trachea would have highest PO2 & alveoli the lowest. Reason for decline as one descends airway b/t: Mixing of "fresh" incoming air mixed w/ "stale" air from last expiration in "dead space" of trachea, bronchi & terminal bronchioles; & Humidification |
PaO2 at rest & at Peak Exercise | No matter how active a healthy person is, even at peak exercise, PaO2 should stay at ~97 mmHg (at sea level) |
PaCO2 at rest & at Peak Exercise | For a healthy person, no matter the level of activity, all the excess CO2 in the blood entering the lungs should be "blown off", keeping the arterial PCO2 at 40 mmHg |
PAO2 | 100 mmHg |
PACO2 | 40 mmHg |
PvO2 at rest | 40 mmHg |
PvCO2 at rest | 46 mmHg |
In a healthy person, oxygen saturation of arterial blood is mainly determined by what? | Arterial O2 saturation determined by PaO2 |
What 2 components of blood determine the O2 carrying capacity of blood? | CaO2 = Hb (gm/dl) x 1.34 mL Ox/gm Hb x SaO2, O2 carrying capacity of blood is determined by the hemoglobin concentration & SaO2 |
A person has a hemoglobin content of 14 gms/dl & a SaO2 of 80. What is the oxygen carrying capacity? | CaO2 = 14 x 1.34 X .80 = 15.0 mL/dl |
What relationship is represented by the oxyhemoglobin dissociation curve? | Relationship b/t available oxygen & amount of oxygen carried by hemoglobin |
What range of the oxyhemoglobin dissociation curve represents PAO2? | Partial pressure of oxygen will remain at the "flat" end of the curve or above 60 mmHg unless one ventures to extremely high altitudes; this end of curve insures O2 sat of at least 90%. <90% is hypoxemia |
When considering % oxyhemoglobin O2 saturation, what is unique about this range? | At the "flat end" the drop of partial pressure from 100 mmHg to 60 mmHg only causes a slight drop in O2 sat from 98-99% to 90% |
What range of oxyhemoglobin dissociation curve represents the tissue PO2 that surrounds systemic capillary beds? | At rest PAO2 is ~40 mmHg which beings at "steep" part of curve; Blood entering cap bed with PAO2 40 mmHg will leave tissue at ~75% saturation; |
What is unique about this range? | Blood leaving at around 55% saturation thus releasing more O2 to the tissue. In this way, the blood can match the needs of the tissue |
In what direction does increasing temperature in the capillary bed shift the oxyhemoglobin dissociation curve? | Right |
In what direction does decreasing temperature in the capillary bed shift the oxyhemoglobin dissociation curve? | Left |
What affect does shifting have on the unloading of O2 into the capillary bed? | Shifting right increases release of oxygen into the capillary bed while a shift left decreases the release of oxygen into the capillary bed |
In what direction does increasing 2,3-DPGin the RBCs shift the oxyhemoglobin dissociation curve? | Increase would shift curve right & results in an increase in the release of O2 into all the systemic capillary beds |
What 2 developments would cause a person's RBCs to increase its concentration of 2,3-DPG? | Any event that causes hypoxia (tissues of body deprived of an adequate supply of O2) will results in increased 2,3-DPG in blood (Ex: hypoxia as result of high altitude/COPD/Fe deficiency anemia) |
What is the ventilation/perfusion ratio? | V/Q is defined at the ratio of the amount of air reaching the alveoli (VA) to the amount of blood reaching the alveoli (Q) |
What affect would "shunting" have on the V/Q ratio & thus oxygenation of blood? | Given that the normal V/Q is ~0.8, shunting would reduce ratio below that toward 0 |
What disease conditions can cause shunting? | Shunting is blocking of airways due to airway edema, bronchoconstriction & increased mucus secretion as a result of asthma or bronchitis/bronchiolitis |
What affect would a "dead space" have on the V/Q ratio & thus oxygenation of blood? | Dead space occurs whe perfusion to a ventilated airspace is blocked |
What disease conditions can cause dead space? | Dead space increases as a result of a pulmonary thromboembolus or acute respiratory distress syndrome (ARDS) |
What is the rhythmicity center & 2 types of neurons are found within it? | Medulla; I neurons (inspiratory neurons) that stimulate motor neurons that innervate respiratory mm & E neurons (expiratory neurons) that inhibit "I" neurons resulting in relaxation of respiratory mm |
Where is the apneustic center & what is its function? | Pons; Stimulates the "I" neurons in the inspiratory center of the medulla |
Where is the pneumotaxic center & what is its function? | Pons; Antagonizes apneustic center & inspiratory center to inhibit respiration |
What are central chemoreceptors located? | Ventrolateral surface of medulla near the CSF of the 4th ventricle |
How are central chemoreceptors stimulated? | Increased PaCO2 results in diffusion of CO2 into CSF. CO2 combines with H2O to form carbonic acid which dissociates into H+ & HCO3 |
Is it CO2 or H+ that directly stimulates central chemoreceptors? | H+ |
Where are peripheral chemoreceptors located? | Carotid & Aortic bodies |
What directly stimulates peripheral chemoreceptors? | Rise in H+ concentration (decrease in pH); on stimulation ventilation rate increases |
What effect does PO2 have on peripheral chemoreceptors? | Low PaO2 (</= 60 mmHg) is necessary to directly stimulate peripheral chemoreceptors; This degree of hypoxemia occurs in extremely severe environments |
pH = 7.52 BE = +2.5 HCO3 = 24 mEq/L PCO2 = 30 mmHg | Respiratory Alkalosis |
pH = 7.11 BE = -17 HCO3 = 12 mEq/L PCO2 = 40 mmHg | Metabolic Acidosis |
pH = 7.57 BE = +13 HCO3 = 36 mEq/L PCO2 = 40 mmHg | Metabolic Acidosis |
pH = 7.24 BE = -11 HCO3 = 15.5 mEq/L PCO2 = 38 mmHg | Metabolic Acidosis |
pH = 7.36 BE = -2 HCO3 = 23 mEq/L PCO2 = 43 mmHg | Normal Blood Gases |
pH = 7.23 BE = +2 HCO3 = 26 mEq/L PCO2 = 60 mmHg | Respiratory Acidosis |