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115 WK 3 notes

Final notes week 3 PHM 115

What is an antibiotic? a naturally occuring substance produced by one organism that is capable of destorying or inhibiting the growth of bacteria.
What is bactericidal? agents that destroy.
What is bacteriostatic? slows the growth.
Who is the host? YOU!
Penicillins, cephalosporins, cabapenems and monobactams are what? B-lactam antibiotics that inibit cell was synthesis.
What are the 5 classes of antiinfective agents? aminoglycosides, macrolides, tetracyclines, amphenicols, and oxzolidiones.
How do the last stated antiinfectives work? They interfer with the bacterias ability to replicate.
Rifampin inhibits what? Bacterial RNA synthesis.
Mechanisms of microbial resistance include what? Secretion of enzymes that inactivate the antibiotic, modification of the ribosomal target, production of antibiotic-modifying enzymes and mutation that change bacterial transport mechanism
Aminoglycosides are effective for treating what? aerobic gram-negative bacilli, staphylococcus, and mycobacterium.
Topical aminoglycosides are prescribed for the treatment of what? blepharitis and conjuctivitis.
Aminoglycosides inhibit bacterial protein synthesis. T or F? True!
Aminoglycosides are administered before what? colorectal surgery.
Serious adverse reactions include what two things? ototoxicity (hearing loss) and nephrotoxicity (kidney damage)
A test used to figure out if its gram negative or gram positive is what? Gram-stain test.
What are the generations of Cephs? 1st, 2nd, 3rd.
1st generations are most effective against what? gram +
2nd generation? Both gram + and gram -
3rd generation? gram negative and anaerobic bacteria.
What routes of aministration are used for Cephs? oral, IM and IV. One 3rd generation is parenterally.
Fluoroquinolones inhibit what? enzyme DNA gyrase.
Fluroquinolones are formulated for what routes? oral, opthmalmic and parenteral.
The FDA in 2007 did what? required package labels for telithromycin to indicate that the drug is contraindicated in individuals with myasthenia gravis due to risk of fatal respiratory failure.
Linezolid is a new antiinfective agent that is indicated for the treatment of gram + bacterial pneumonia and skin structuce infections. It is limited due to what? side effects and in order to the limit the development of bacterial resistance.
Linezolid does what? inhibits bacterial protein synthesis
Oral penicillins are used to treat what? upper resp, otitis media, skin and strep.
Ampicillin is used to treat what? PID
What are the differences between penicillins and carbapenems? P inhibit the synthesis of the cell wall. C inhibit the 3rd step in bacterial cell wall synthesis.
GI side effects are the most common adverse reaction with what? Penicillins.
Sulfonamides are the earliest what? antiinfective agents.
Tetracyclines do what? inhibit protein synthesis.
Isoniazid is used for what? TB
Chloramphenicol is what? A broad spectrum antiifective.
Clindamycin is used for what? Acne and vaginosis.
Created by: dmhehr