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Pharm exam #3!

heart and GI

TermDefinition
mucus in the GI Protection
glands of the stomach cardiac, pyloric, gastric(the cells of the gastric gland are the largest in number and of primary importance when discussing acid control
Parietal (cells of the gastric gland) produce and secret HCL, primary site of action for many of the drugs used to treat acid-related disorders, helps control ulcers
Chief cells (cells of the gastric gland) secrete pepsinogen (a pro-enzyme)
pepsinogen becomes pepsin when activated by exposure to acid and it breaks down proteins (proteolytic)
Mucous cells surface of epithelial cells, provide a protective mucus coat, protect against self-digestion by HCL and digestive enzymes
Hydrochloric Acid Maintains the stomach at a PH of 1 to 4, secreted by the parietal cells when stimulated by food, caffeine, chocolate and alcohol.
Hydrochloric Acid Acidity aids in the proper digestion of food and defenses against microbial infection via the GI tract.Secretion also stimulated by large fatty meals or emotional stress.
Peptic ulcer disease (acid-related diseases) Gastric or duodenal ulcers that involve digestion of thr GI mucosa by the enzyme pepsin.
Helicobacter Pylori (acid-related diseases) Bacterial infection, Bacterium found in GI tract of 90% of patients with duodenal ulcers and 70% of those with gastric ulcers.
Helicobacter Pylori First line therapy includes a 10-14 day course of a proton pump inhibitor and antibiotics.
Stress related mucosal damage GI lesions are a common finding in ICU patients, factors are decreased blood flow, mucosal ischemia, hypo-perfusion and re-perfusion injury.
Stress related mucosal damage nasogastic tubes and ventilators predispose patients to GI bleeding. A histamine receptor-blocking drug or a proton pump inhibitor are given for prevention.
Types of acid controlling
Created by: eliseduran
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