Save
Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't know
Remaining cards (0)
Know
0:00
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Pharm 45 Immunosuppr

Pharm

QuestionAnswer
Inhibit inosine monophosphate dehydrogenase (IMPDH)->no guanosine for solid organ transplant, Lupus nephritis, RA. SE: HTN, periph edema. Don't take w iron (reduces bioavailability). Mycophenolic acid, Mycophenolate mofetil
Inhibit dihydroorotate dehydrogenase (DHOD)->no pyrimidine for RA. SE: HTN, hepatotox, alopecia. Contra: Preg Leflunomide
Inhibit phosphatase activity of calcineurin (mediates T-cell activation) also inhibits IL-2 production from T-cells for Keratoconjunctivitis sicca (topical). SE: Nephrotox, HTN, neurotox, hepatotox, infx, gingival hyperplasia, hyperlipid, hirsutism Cyclosporine
Complex w FK-binding prot inhibits calcineurin for organ transplant, atopic dermatitis (topical). SE: nephrotox, HTN, prolong QT, hypergly, alopecia Tacrolimus
Complex w FK-binding prot inhibits mTOR for prophylax of renal transplant rejection, cardiac stents. SE: HTN, periph edema, infx, alopecia Sirolimus (Rapamycin)
TNF receptor dimer (inhibits both TNF-Alpha and Beta) for RA, Juvenile Idiopathic Arthritis, plaque psoriasis, Ankylosing spondylitis. SE: Myelosuppress, heart fail, optic neuritis, REACTIVATE TB. Contra: Sepsis, heart fail. Etanercept
Monoclonal antibod that binds to TNF-Alpha selectively for RA, Crohn's, UC, Anklylosing spondylitis. SE: myelosuppress, heart fail, optic neuritis, REACTIVATE TB. Infliximab - partially human mouse antibod Adalimumab - also for JIA, not for UC. Golimumab - not for UC or Crohn's. also fully human IgG1 antibod w longer half-life than adalim Certolizumab - only Crohn's. pegylated anti-TNF-Alpha antibod fr
IL-12 and IL-23 p40 inhibitor for Plaque psoriasis. SE: infx, URI. Ustekinumab
IL-1 receptor antagonist for RA (reduces bony erosions). SE: neutropenia, infx. Anakinra
IL-1 inhibitor for Cryopyrin-asso periodic fever synds (familial cold autoinflamm synd and Muckle-Wells synd). SE: infx. Rilonacept: soluble IL-1 receptor FC fusion prot Canakinumab: IgG1 monoclonal antibod to IL-1Beta
Antibod to IL-6 receptor for RA. SE: infx, GI perforation. Contra: live vaccines. Tocilizumab
Polyclonal bunny/horse antibod against T-cell epitopes for Renal transplant, aplastic anemia. SE: cytokine release synd (cytokine storm=fever, shaking, chills, myalgia, HA), infx. Antithymocyte globulin (ATG)
Mouse monoclonal antibod against CD3 for Organ transplants. SE: Cytokine release synd(cytokine storm=fever, shaking, chills, myalgia, HA), infx. Contra: heart fail, seizure, Preg/breastfeed OKT3
Anti-CD20 antibod for B-cell NHL, CLL, RA. SE: immunosuppress, progressive multifocal leukoencephalopathy (PML), tumor lysis synd. Rituximab
Antibod to CD25 (high affinity IL-2 receptor) for organ transplant. SE: immunosuppress, progressive multifocal leukoencephalopathy (PML), tumor lysis synd. Daclizumab
Antibod to CD52 (campath-1) for CLL. SE: immunosuppress, progressive multifocal leukoencephalopathy (PML), tumor lysis synd. contra: active infx Alemtuzumab
inhibit T-cell activation by binding to CD2 for Psoriasis. SE: immunosuppress, progressive multifocal leukoencephalopathy (PML), tumor lysis synd. Contra: HIV. Alefacept
Prevents co-stimulatory signal->T-cell anergy and apoptosis for RA refractory to methotrexate or TNF-Alpha inhibitors. SE: COPD Abatacept
Monoclonal antibod against alpha-4 integrin for MS, Crohn's. SE: PML. Contra: PML. Natalizumab
Monoclonal antibod against C5 (part of MAC) for Paroxysmal Nocturnal Hemoglobinuria. SE: infx. Contra: N. meningitidis. Monitor pts for intravasc hemolysis and elevated LDH after discontinuing tx. Eculizumab
Created by: Jakphooey
 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards