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Pharm 33 Anitbacter

Pharm

QuestionAnswer
Inhibit bacterial DNA gyrase (Topo II) for gram neg infx. SE: cartilage damage, tendon rupture, periph neuropath. Bactericidal Quinolones: -floxacin (Ciprofloxacin, Levofloxacin)
Inhibit bacterial RNA synth for Mycobac tuberculosis, prophylax for meningitis. SE: Thrombocytopenia, hepatotox, orange fluids, elevated LFTs. Contra: Neisseria meningitidis. Rifabutin (don't take w clarithromycin), Rifampin (used with Isoniazid, Pyrazinamide, Ethambutol [RIPE] for TB)
Binds to 16S rRNA of 30S, bactericidal, synergistic w Beta-lactams for serious gram neg infx. SE: ototox. Aminoglycosides: Amikacin, Gentamicin, Kanamycin, Streptomycin
Binds to 16S rRNA of 30S, bacteriostatic, alternative tx for Gonorrhea. Spectinomycin
Binds to 16S rRNA of 30S, bacteriostatic for Corynebacterium acne, H. influ, V. cholerae, spirochetes, Myco. pneumo, Chlamydia. SE: bulging fontanelle, discolored and hypoplastic teeth, photosense, rash. Contra: later preg, child <8. Take on empty stomach Tetracyclines: -cycline (Doxycycline [for renal impaired and malaria prophylax], Methacycline, Tetracycline)
Binds to 23S rRNA of 50S, bacteriostatic for Coryne acne, Legionella, Syphilis, Myco pneumo, Chlamydia, H. influ, Morax cat. SE: hepatitis, ototox. Inhibit P450. Macrolides: Azithromycin (H. influ, Morax cat), Clarithromycin (H. influ), Erythromycin (all the other stuff)
Binds to 23S rRNA of 50S, bacteriostatic, broad-spec for anaerobes and rickettsiae. SE: Hemolytic anemia w low G6PD, aplastic anemia, GRAY BABY. Chloramphenicol - antagonizes bactericidal effects of penicillins and aminoglycosides
Binds to 23S rRNA of 50S, bacteriostatic for anaerobes. SE: PSEUDOMEMBRANOUS COLITIS (overgrowth of C. difficile), elevated LFTs, jaundice. Clindamycin
Binds to 23S rRNA of 50S, bactericidal for Vancomycin-resistant E. faecium (VREF), S. aureus and Strep pyogenes skin infx. Contra: not w SSRIs (serotonin synd). Streptogramins: Dalfopristin/Quinupristin
Binds to 23S rRNA of 50S, bacteriostatic for VRE, MRSA. SE: Myelosuppress, periph neuropath, optic neuropath. Linezolid
Created by: Jakphooey
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