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Pharm 32 Antimicro
Pharm
Question | Answer |
---|---|
PABA analogue inhibits dihydropteroate synthase for vaginal infx, toxoplasmosis, traveler's diarrhea, UTI, otitis media. SE: Kernicterus (newborn). Contra: infants, preg, breastfeed, megaloblast anemia d/t folate def. | Sulfonamides - sulfanilamide: vaginal infx - sulfadiazine: toxoplasmosis - sulfamethoxazole (w TMP): otitis media, UTI |
PABA analogue inhibits dihydropteroate synthase for Leprosy. SE: hemolytic anemia, methemoglobinemia. Contra: G6PD def. | Dapsone |
Inhibit microbial dihydrofolate reductase for UTI, otitis med, traveler diarrhea. SE: Stevens-Johnson synd, megaloblastic anemia. Contra: Megaloblastic anemia d/t folate def. Bacteriostatic. | Trimethoprim (TMP) - taken w sulfamethoxazole (TMP/SMX) freq |
Inhibit parasitic dihydrofolate reductase for toxoplasmosis, malaria. SE: Stevens-Johnson synd, megaloblastic anemia. Contra: Megaloblastic anemia d/t folate def. | Pyrimethamine - taken w sulfadiazine for toxoplasmosis |
Antineoplastic inhibitor of mammalian dihydrofolate reductase for breast, lung, head/neck carcinomas, ALL, psoriasis, RA, early ectopic preg. SE: Myelosuppress, liver fail, GI hemorrhage, alopecia. Contra: Preg, breastfeed, alcohol. Folinic acid rescue. | Methotrexate |