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Pharm 23 <3 Rhythm


IA antiarrhythmic blocks Na channel for atrial flutter/fibrillation and PSVT. SE: Torsades de pointe. contra: hx torsades, myasthenia gravis, other QT drugs. Drug effects (reduce codeine's anlagesia, digoxin tox), use w Beta-blocker or Ca chan blocker Quinidine
IA antiarrhythmic blocks Na channel for life threatening VT. SE: lupus-like. Contra: SLE and other QT prolong drugs. Procainamide
IA antiarrhythmic blocks Na channel for PVC's, VT. SE: same as quinidine w greater antichol effects and less GI. Contra: trosades, QT prolong drugs, Myasthenia gravis. For pts who cant tolerate quinidine or procainamide Disopyramide
IB anti-arrhythmic blocks Na chan for Ventric arrhythmia from MI, cardiac glycosides, and local anesthesia. SE: seizures, asystole, bradycardia, stupor, tremor. Contra: Stokes-Adams, WPW. Lidocaine
IB anti-arrhythmic blocks Na chan for life-threat vent arrhythmia and in combo w other antiarrhythmics (amiodarone for pts w implant defibs). SE: nausea, tremor. Take w food. Mexiletine (oral analogue of Lidocaine)
IB anti-arrhythmic blocks Na chan for Seizures and ventricular arrhythmias. SE: agranulocytosis, ataxia, nystagmus, gingival hyperplasia, hirsutism, diplopia. P450 inducer Phenytoin
IC anti-arrhythmic blocks Na chan for SVT, PSVT unresponsive to other drugs. SE: cardiac arrest, heart fail. Contra: heart shock. asso w excessive mortality, can worsen arrhythmias. Flecainide, Encainide
Class III anti-arrhythmic blocks K chan for atrial fib/flutter. SE: AV block, bradycardia, SVT, torsades. Contra; long QT, torsades. Ibutilide, Dofetilide (oral)
Mixed Class II/Class III anti-arrhythmic blocks K chan for life-threat ventricular arrhythmia. SE: bradycardia, torsades, V tach, chest pain, dyspnea. Contra: sinus node dysfnx, long QT, asthma. Sotalol - when pts cant tolerate amiodarone
Class III anti-arrhythmic blocks K chan for recurrent ventri fib., atrial fib. SE: arrhythmias, asystole, bradycardia, pancytopenia, hepat fail, pulm tox, thyroid dysfnx, blue-gray skin. Many drug interactions Amiodarone
Class IV anti-arrhythmic blocks Ca chan for prinzmetal angina Verapamil, Diltiazem
Inhibits SA nodal, atrial, and AV nodal conduction. For PSVT. SE: facial flush, bronchoconstrict (w asthma), chest pressure. Contra: atrial fib/flutter Adenosine
For chronic angina pectoris. SE: prolong QT, constipation, dizzy, HA. Avoid w drugs that prolong QT, w P450 inhibs, and w severe renal impair or hepat dysfnx Ranolazine
Created by: Jakphooey



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