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CNS depressants1
Sensory & Neuro
| Question | Answer |
|---|---|
| Benzodiazapine names | usually end in "pam" |
| Benzodiazapine action | hypnotic that causes sedation and promotes sleep |
| Benzodiazapine side affects | drowsiness, dizziness, sedation, confusion, withdrawal (do not stop medication suddenly) |
| Benzodiazapine interventions | watch for sings of toxicity such as slurred speech, uncoordinated muscle movement, respiratory depression, and ataxia (lack of coordination) |
| Benzodiazapine administration | give 30 minutes before bedtime |
| Benzodiazapine instructions | don't take with other CNS depressants or alcohol |
| Non-benzodiazapine names | Ambien, Sonata, Lunesta |
| Non-benzodiazapine action | same as benzodiazapines |
| Non-benzodiazapine side affects | drowsiness, dizziness, confusion, anxiety, and diplopia (double vision) |
| Non-benzodiazapine administration | give just before bed time on an empty stomach for best effects |
| Non-benzodiazapine instructions | do not take with other CNS depressants or alcohol |
| Centrally acting muscle relaxants (CAMR) names | Lioresal, Soma, Paraflex, and Flexeril |
| CAMR action | enhance inhibitory effects of GABA in spinal cord. for muscle spasms |
| CAMR side affects | drowsiness, dizziness, nausea, and constipation |
| CAMR instructions | start with low dose and gradually increase. give with food or milk. Don't stop drug abruptly |
| CAMR contraindications | don't give if MAOI's have been given in the past two weeks |
| Peripherally acting muscle relaxants (PAMR) | Dantrium |
| PAMR action | act directly on skeletal muscle to inhibit the release of calcium to block contraction of muscle. for muscle spasms |
| PAMR side affects | muscle weakness, drowsiness, dizziness, and diarrhea |
| PAMR instructions | monitor for diarrhea, muscular weakness, and cardiac dysrhythmias. do not give to patients with liver disease |
| Hydantoin names | Dilantin, Peganone, Cerebyx. Generic names of these end in "toin" |
| Hydantoin action | for seizures. inhibits influx of sodium |
| Hydantoin side affects | drowsiness, gingival hyperplasia, withdrawal |
| Hydantoin instructions | take with meals, keep serum levels between 10-20 mcg/mL, soft bristled tooth brush, don't stop abruptly |
| Iminostilbene names | carbamazapine (Tegretol) |
| Iminostilbene action | same as Hydantoin |
| Iminostilbene side affects | visual disturbances, fluid retention |
| Iminostilbene interventions | gradually increase dose, split dose and give larger dose before bed, if any blood cell counts are below normal withhold drug |
| Iminostilbene instructions | take with food, grapefruit juice may increase plasma levels, may produce negative false pregnancy test |
| Valproic acid names | Depakote, Depacon, Depakene |
| Valproic acid action | inhibits the influx of Na and Ca and increases the inhibitory effects of GABA. for seizures. |
| Valproic acid side affects | GI upset, bruising, bleeding, decreased platelets |
| Valproic acid interventions | monitor bleeding time, platelets, and for bruising. |
| Local anesthesia names | lidocaine and novocaine |
| Local anesthesia action | for pain. inhibits influx of Na |
| Local anesthesia side affects | respiratory depression and hypotension |
| Local anesthesia interventions | if hypotension occurs, lower the head of the bed. if it worsens, prepare to administer ephedrine or phenylephrine |
| General anesthesia/barbiturates (GA/B) names | Pentothal, Brevital |
| GA/B action | for hypnosis for quick procedures. enhances inhibitory effects of GABA |
| GA/B side affects | decreased HR, decreased BP, respiratory depression |
| GA/B instructions | Use of this drug with other CNS depressants may increase respiratory depression. herbals kava kava and valerian increase the sedation |
| General anesthesia/benzodiazapine (GA/Benzo) names | Versed, Valium |
| GA/Benzo action | to help cause sedation before giving general anesthesia |
| GA/Benzo side effects | amnesia, cardiac arrest, respiratory arrest |
| General anesthesia/opioids (GA/O) names | Fentanyl |
| GA/O action | narcotic agonist of analgesia and sedation |
| GA/O side affects | nausea, sedation, respiratory depression, and circulatory depression |
| GA/O instructions | don't administer within 2 weeks of having MAOI's to avoid a hypertensive crisis. don't give with other CNS depressants |