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pharmacolgy 2 exam 3

drugs/indications

QuestionAnswer
octreotide long acting somatosatin analog, suppresses growth in acromegaly, t1/2 ~80 min
Pegvisomant injection, GH receptor competitive antagonist in acromegaly, goal to normalize serum IGF-1 levels, polyethylene glycol reduces clearance
mecasemin recombinant IGF-a with IGF binding protein for long t1/2. for GH insensitive dwarfism and IGF-a deficiency
sermorelin synthetic GHRH, mimics GHRH for diagnostic uses
replacement growth hormone used for hypopituitary dwarfism, conditions of growth failure in children
replacement FSH, LH, hCG induce ovulation in women with anovulation due to hypogondadotropic hypogonadism, PCOS, obesity and other causes, also controlled ovarian hyperstimulation in assisted reproductive technology procedures. in males- FSH and LH to induce sperm production
urofollitropin purified human FSH, stimulate ovulation for invitro fertilization
follitropin recombinant FSH, used to stimulate ovulation for invitro fertilization
cetrorelix GnRH antagonists, control ovarian stimulation by suppressing the LH surge
ganirelix GnRH antagonists, control ovarian stimulation by suppressing the LH surge
abrarelix GnRH antagonist, used in treating prostate cancer, inhibit secretion of LH and FSH
bromocriptine D2 agonists, treat hyperprolactinemia, restore ovulation, also acromegaly and parkinsons
cabergoline D2 agonists, treat hyperprolactinemia, restore ovulation, also acromegaly and parkinsons
cosyntropin mimetic of ACTH, diagnostic agent in people with adrenal insufficency
CRH diagnostic agent to evaluate HPA axis
oxytocic drugs used to induce labor, improve labor and prevent postpartum bleeding
oxytocin (syntocinon) milk ejection, induce labor, etc
octapressin uterine contraction, milk let down process
vasopressin injection (petressin) synthetic ADH for diagnosis of diabetes insipidus (v2), postoperative abdominal distention/radiography (v1)
lypressin (diapid) diabetes insipidus (v2)
terlipressin (glypressin) specific for v1 receptor hypotension (septic shock), bleeding esphageal varices
Sodium levothyroxine (synthroid) hypothyroidism (DOC)
sodium liothyronine (cytomel) hypothyroidism
liotrix (euthroid) hypothroidism
radioactive sodium iodide treatment for throtoxicosis, alternative to surgery in hypothyroidism
radioactive iodide hyperthyrodism, diagnostic use
stable inorganic iodide prevent endemic goiter and hypothyroidism
iodine (poassium iodide solution USP, strong iodine solution [lugols solution]) treat hyperthyroidism, decrease vascularity, size, fragility of the hyperthyroid gland in preparation for surgical removal – preoperative use, Reduce thyroidal uptake of radioactive iodine in cases of accidental exposure
propylthiouracil treat hyperthyroidism- inhibit peroxidases in thyroid gland
methimazole treat hyperthyroidism- inhibit peroxidases in thyroid gland
tolbutamide (orinase) 1st generation sulfonyureas, treatment of type 2 DM, inhibit ATP-sensitive K+ channel and stimulate insulin secretion
chlorpropamide (diabinese) 1st generation sulfonyureas, treatment of type 2 DM, inhibit ATP-sensitive K+ channel and stimulate insulin secretion
tolazamide (tolinase) 1st generation sulfonyureas, treatment of type 2 DM, inhibit ATP-sensitive K+ channel and stimulate insulin secretion
glipizide (glucotrol) 2nd generation sulfonyureas, treatment of type 2 DM, inhibit ATP-sensitive K+ channel and stimulate insulin secretion
glyburide (micronase) 2nd generation sulfonyureas, treatment of type 2 DM, inhibit ATP-sensitive K+ channel and stimulate insulin secretion
glymepiride (amaryl) 2nd generation sulfonyureas, treatment of type 2 DM, inhibit ATP-sensitive K+ channel and stimulate insulin secretion
repaglinide (pradin) meglitinide, closes K+ channel and induces beta-cell depolarization and insulin release (similar to SU)
nateglinide (starlix) meglitinide, closes K+ channel and induces beta-cell depolarization and insulin release (similar to SU)
pioglitazone (actos) thiazolidinediones, require insulin, reduces insulin resistance
troglitazone thiazolidinediones, require insulin, reduces insulin resistance
rosiglitazone (avandia) thiazolidinediones, require insulin, reduces insulin resistance
metformin (glucophage) biguanides, first line therapy for T2DM
acarbose alpha-glucosidase inhibitors, delay and reduce uptake of carbohydrates across the intestine and reduce postprandial rise in blood glucose
miglitol alpha-glucosidase inhibitors, delay and reduce uptake of carbohydrates across the intestine and reduce postprandial rise in blood glucose
sitagliptin (januvia and galvus) dipeptidyl peptidase iv inhibtops, treat T2DM
exenatide (byetta) incretin mimetics, stimulates insulin secretion, treat T2DM
lispro rapid insulin
aspart rapid insulin
insulin glulisine rapid insulin
regular insulin rapid insulin
NPH intermediate insulin
aspart protamine intermediate insulin
glargine slow insulin
insulin detemir slow insulin
pramlintide acetate (symlin) given at meal times with insulin
streptozotocin selectively destroys islet beta cells by alklating the bases in DNA, used to treat insulin secreting tumors
Diazoxide opens ATP dependent K+ channels, hyperglycemic agent
alloxan not used therapeutically, inhibits glucose interaction with beta cell glucokinase
Created by: Kachmiel
 

 



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