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ccctc test 10

defenitions for test 10

QuestionAnswer
the uncontrolled growth and spread of abnormal human cells. difficult to treat because drugs cannot differentiate between cancer and normal cells and; therefore, both normal and cancer cells are killed. cancer
rescue therapy. some protocols use massive amounts of chemotherapy to kill off cancer cells. this treatment is given over a short period followed by an antidote drug immediately thereafter to spare the normal cells. leucovorin
mechanism of action for anti-metabolites mimics a neccessary nutrient or blocks a reaction, which synthesizes a necessary nutrient. cancer cells utilize these agents faster than normal cells and; therefore, are killed more quickly than normal cells.
side effects of anti-metabolites bone marrow depression, hepatotoxicity, immunosuppression, anorexia, nausea/vomiting, oral and anal ulcers, fever, rash, hair loss.
fluorouracil 5-FU, efudex, adrucil
what should you do when preparing fluorouracil gloves should be worn to prevent application to areas not intended to use. this compound can be an irritant to the skin.
mercaptopurine 6-MP
methotrexate mexate
what should you use when preparing methotrexate utilize leucovorin as an antidote
uses for alkylating agents to treat leukemia, testicular and ovarian cancers, and bladder cancers.
mechanism of action for alkylating agents bind to DNA(the genetic material of the cell) and prevent its relocation; utilized to a greater extent in cancer cells; caution should be used during reconstitution because these agents can cause severe itching and burning upon contact.
notes for the technician when using alkylating agents the technician, when accidentally having skin contact with a cytotoxic drug, should wash hands thoroughly with soap and water immediately and seek medical attention. cytotoxic drugs must be prepared in a vertical hood to protect the technician.
side effects of alkylating agents nausea/vomiting/diarrhea, testicular atrophy, impotence, bone marrow suppression, hepatotoxicity, nephrotoxicity, rash, loss of taste and hearing, seizures, mental cloudiness, depression.
camustine BCNU
buslfan myleran
chlorambucil LEUKERAN
CISPLATIN PLATINOL
mechlorethamine nitrogen mustard
cyclophosphamide cytoxan
ifosfamide ifex
carboplatin paraplatin
lomustine ceeNU
dacarbazine DTIC-Dome
nedaplatin aqupla
use for hormones to treat hormone dependant cancers such as breast cancer. both natural and synthetic hormones are used
side effects of hormones nausea/vomiting/diarrhea, hot flashes, insomnia
tamoxifen nolvadex
mechanism of action for female hormones blocks effect of estrogen in target tissues such as breast tissue
side effects of female hormones hot flashes
anastrozole arimidez
What is anastrozole (arimidex) used for breast cancer
bicalutamide casodex
vinblastine velban
vincristine oncovin
vinorelbine navelbine
mechanism of action for vinca alkaloids arrests mitotic division at the metaphase of cell division
side effects of vinca alkaloids bone marrow suppression, nausea/vomiting, hair loss
mechanism of action for asparanginase (elspar) blocks asparagine dependent protein synthesis in tumor cells
side effects of asparaginase (elspar) hypersensitivity, bone marrow suppression, bleeding, depression, nausea/vomiting
mechanism of action for antibiotics inhibits nucleic acid synthesis
side effects of bleomycin pulmonary fibrosis, fever, chills, nausea/vomiting
side effects of doxorubicin myelosuppression, cardiotoxicity, nausea/vomiting
side effects of mitomycin bone marrow toxicity, nausea/vomiting
bleomycin blenoxane
doxorubicin adriamycin
mitomycin mutamycin
dactinomycin cosmegen
idarubicin idamycin
mitoxantrone novantrone
topotecan hycamtin
plicamycin mithracin
daunorubicin daunoxone
epirubicin ellence
the above antibiotics are biohazardous if spilled, they must be cleaned with a spill kit
Created by: kfpolchies
 

 



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