click below
click below
Normal Size Small Size show me how
ccctc test 10
defenitions for test 10
Question | Answer |
---|---|
the uncontrolled growth and spread of abnormal human cells. difficult to treat because drugs cannot differentiate between cancer and normal cells and; therefore, both normal and cancer cells are killed. | cancer |
rescue therapy. some protocols use massive amounts of chemotherapy to kill off cancer cells. this treatment is given over a short period followed by an antidote drug immediately thereafter to spare the normal cells. | leucovorin |
mechanism of action for anti-metabolites | mimics a neccessary nutrient or blocks a reaction, which synthesizes a necessary nutrient. cancer cells utilize these agents faster than normal cells and; therefore, are killed more quickly than normal cells. |
side effects of anti-metabolites | bone marrow depression, hepatotoxicity, immunosuppression, anorexia, nausea/vomiting, oral and anal ulcers, fever, rash, hair loss. |
fluorouracil | 5-FU, efudex, adrucil |
what should you do when preparing fluorouracil | gloves should be worn to prevent application to areas not intended to use. this compound can be an irritant to the skin. |
mercaptopurine | 6-MP |
methotrexate | mexate |
what should you use when preparing methotrexate | utilize leucovorin as an antidote |
uses for alkylating agents | to treat leukemia, testicular and ovarian cancers, and bladder cancers. |
mechanism of action for alkylating agents | bind to DNA(the genetic material of the cell) and prevent its relocation; utilized to a greater extent in cancer cells; caution should be used during reconstitution because these agents can cause severe itching and burning upon contact. |
notes for the technician when using alkylating agents | the technician, when accidentally having skin contact with a cytotoxic drug, should wash hands thoroughly with soap and water immediately and seek medical attention. cytotoxic drugs must be prepared in a vertical hood to protect the technician. |
side effects of alkylating agents | nausea/vomiting/diarrhea, testicular atrophy, impotence, bone marrow suppression, hepatotoxicity, nephrotoxicity, rash, loss of taste and hearing, seizures, mental cloudiness, depression. |
camustine | BCNU |
buslfan | myleran |
chlorambucil | LEUKERAN |
CISPLATIN | PLATINOL |
mechlorethamine | nitrogen mustard |
cyclophosphamide | cytoxan |
ifosfamide | ifex |
carboplatin | paraplatin |
lomustine | ceeNU |
dacarbazine | DTIC-Dome |
nedaplatin | aqupla |
use for hormones | to treat hormone dependant cancers such as breast cancer. both natural and synthetic hormones are used |
side effects of hormones | nausea/vomiting/diarrhea, hot flashes, insomnia |
tamoxifen | nolvadex |
mechanism of action for female hormones | blocks effect of estrogen in target tissues such as breast tissue |
side effects of female hormones | hot flashes |
anastrozole | arimidez |
What is anastrozole (arimidex) used for | breast cancer |
bicalutamide | casodex |
vinblastine | velban |
vincristine | oncovin |
vinorelbine | navelbine |
mechanism of action for vinca alkaloids | arrests mitotic division at the metaphase of cell division |
side effects of vinca alkaloids | bone marrow suppression, nausea/vomiting, hair loss |
mechanism of action for asparanginase (elspar) | blocks asparagine dependent protein synthesis in tumor cells |
side effects of asparaginase (elspar) | hypersensitivity, bone marrow suppression, bleeding, depression, nausea/vomiting |
mechanism of action for antibiotics | inhibits nucleic acid synthesis |
side effects of bleomycin | pulmonary fibrosis, fever, chills, nausea/vomiting |
side effects of doxorubicin | myelosuppression, cardiotoxicity, nausea/vomiting |
side effects of mitomycin | bone marrow toxicity, nausea/vomiting |
bleomycin | blenoxane |
doxorubicin | adriamycin |
mitomycin | mutamycin |
dactinomycin | cosmegen |
idarubicin | idamycin |
mitoxantrone | novantrone |
topotecan | hycamtin |
plicamycin | mithracin |
daunorubicin | daunoxone |
epirubicin | ellence |
the above antibiotics are biohazardous | if spilled, they must be cleaned with a spill kit |