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bacterial coverage
bacterial coverage by class
Drug Class | BACTERIA it COVERS | COVERS SOME | DOES NOT COVER |
---|---|---|---|
Carboxy-penicillins (Carbenicillin, Ticarcillin) | Streptococcal Spp., EXCELLENT gram negative activity (including pseudomonas) (Ticarcillin > Carbenicillin against pseudomonas) | Intermediate enterococcus spp. coverage | N/A |
Ureido-Penicillins (Azlocillin, Mezocillin, Piperacillin) | Streptcoccal spp., Enterococcus spp., BL-S. aureus, EXCELLENT gram negative activity (including pseudomonas - better than carboxy) | Some against gram negative anaerobes (including bacteroides fragilis) | N/A |
Beta-lactam combos (unasyn, augmentin, tymentin, zosyn) | extended gram negative (but not pseudomonas) extended gram positive (Includes MSSA but not MRSA), Extended gram negative anaerobic bacilli | N/A | N/A |
Penicillins Overall | GRAM + aerobes super good, | Most cover enterococcus except nafcillin, dicloxacillin, and carbenicillin) | NO MRSA NO Atypicals |
1st Generation Cephalosporin (Cefazolin, cephalexin, cefadroxil) | Streptcoccal spp. MSSA | limited gram negative | NO enterococcal |
2nd Generation Cephalosporin, group 1 (Cefuroxime, cefaclor) | streptoccal spp. MSSA | limited gram negative (E. coli, H. influenzae, K. pneumoniae) | NO enterococcal NO pseudomonas No gram negative |
2nd Generation Cephalosporin, group 2 (Cefoxitin, Cefotetan, Cemetazole) | Enhanced activity against enterobacteriaeceae | Limited streptococcal spp. limited MSSA | NO enterococcal no pseudomonas |
3rd Generation Cephalosporin, (normal) (Ceftriaxone, Cefixime, Cefpodoxime proxetil) | Excellent streptoccal spp. activity, Excellent gram negative activity (E. coli, H. influenzae, K pneumoniae, Proteus spp) | moderate MSSA activity | NO enterococcal no pseudomonas little to no gram negative anaerobic activity |
3rd generation cephalosporin (antipseudomonal) (Ceftazidime, Cefoperazone) | NO enterococcal | ||
4th Generation Cephalosporin (Cefepime) | NO enterococcal | ||
5th Generation Cephalosporin (Ceftaroline) | NO enterococcal | ||
Cephalosporins overall | Gram + aerobes | Most cover MSSA (not so much ceftazidime) Most cover gram negative aerobes | No enterococcus No MRSA (EXCEPT ceftaroline) NO Gram negative anaerobes (except cefoxitin) No atypicals |
Natural Penicillins (Penicillin G and Penicillin V) | Streptococcal spp. Enterococcus spp. Treponema pallidum(DOC), | Cover SOME: anaerobic streptococci (peptococcus and peptostreptococcus) | NO Gram negative, NO pseudomonas aeruginosa |
Aminopenicillins (Ampicillin and amoxicillin) | same as natural penicillins (Streptococcal spp., Enterococcus spp., Treponema pallidum) but, EXTENDED gram negative (H. influenzae, E. coli, K. pneumoniae), -enhanced activity against enterococcus spp. NO | N/A | No pseudomonas aeruginosa |
Penicillinase Resistant Penicillins (Oxacillin, nafcillin, cloxacillin, dicloxacillin) | Streptococcal spp. Staphlococcus aureus (DOC for MSSA) | N/A | NO gram negative (including pseudomonas) NO MRSA, NO Enterococcus |