Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Didn't know it?
click below
Knew it?
click below
Don't know
Remaining cards (0)
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Pharm 37 Antivirals


Blocks infx of HIV that uses CCR5 (not active against CXCR4). SE: Hepatotox, MI, rash, dizzy. In combo w other HIV drugs Maraviroc
Blocks HIV attach/entry by inhibiting gp41-mediated fusion. SE: Guillain-Barre synd, Renal insuff, Periph neuropathy, CN6 palsy. In combo w other HIV drugs Enfuvirtide (T-20)
Inhibit Influenza A uncoating by blocking M2-> acidify virus. Also Tx Parkinsonsim. SE: Neuroleptic Malignant synd. Amantadine - Rimantadine causes fewer neuro effects
Phosphorylated by viral kinases->inhibit viral DNA polymerase. For HSV and VZV. SE: Renal fail, TTP in immunocompromised. Acyclovir - Valacyclovir is oral prodrug
Phosphorylated by viral kinases->inhibit viral DNA polymerase. For HSV and VZV. SE: Erythema Multiforme Penciclovir, Famciclovir
Phosphorylated by viral kinases->inhibit viral DNA polymerase. For CMV. SE: Neutropenia, Thrombocytopenia, Anemia. Ganciclovir - Valganciclovir is oral prodrug
Phosphorylated by cellular enzymes->inhibit CMV DNA Polymerase. For CMV Retinitis. SE: Nephrotox, Neutropenia. Contra: Renal insuff. Must be coadmin w Probenecid. Once/week dosing Cidofovir
Anti-HIV nucleoside analogue is phosphorylated by cell kinases->inhibt viral Reverse Transcriptase. For HIV. SE: Neutropenia, anemia, Pancreatitis. Tox d/t inhib of mitochon DNA pol Zidovudine (AZT), Emtricitabine (FTC) [1/day]
Anti-HBV nucleoside analogue is phosphorylated by cell kinases->inhibt HBV Polymerase. For Hep B. SE: Neutropenia, anemia, Pancreatitis. Less toxic d/t L-stereoisomer structure Lamivudine (3TC)
Inhibit viral DNA Polymerase directly by mimicking Pyrophosphate. For HSV and CMV. SE: Renal impair (Major dose-limiting tox). Foscarnet
Non-Nucleoside Reverse Transcriptase Inhibitor (NNRI). For HIV. SE: Rash, Psych effects. Contra: Drugs metab by P450 3A4. Resistance develops rapidly so used in combo w other anti-HIV drugs Efavirenz, Nevirapine
Inhibit Integrase (HIV can't integrate into host genome). SE: Suicide, Renal Fail, Rhabdomyolysis, Insomnia. Only used in combo Raltegravir
Inhibit HIV protease (no maturation). SE: Dyslipidemia. Contra: Hepat impair, P450 3A4s. Saquinavir, Ritonavir, Fosamprenavir (oral)
Inhibit Influenza Neuraminidase. For both A and B. SE: Bronchospasm, Resp Depression. Oseltamivir (oral, for Tx and prophylaxis and Tx of Avian and Swine Flus), Zanamivir (inhaled, only for Tx)
Aerosol form for RSV and in combo w Interferon-Alpha for Hep C. SE: Bradyarrhytmia, rash. Contra: Preg (or potential), Heart/Hepat problems Ribavirin
For HSV. SE: Headache. Mech of action unknown, but lacks cytotoxicity Docosanol
Activate signaling cascades to produce antiviral prots (prot kinase R). For Hep C and B, Kaposi Sarcoma, CML. SE: Gastric hemorrhage, Aplastic Anemia, Depression. Interferon-Alpha
Interacts w Toll-like Receptors to boost innate immunity. For HPV. SE: Skin irritation (redness, erosion, crusting, burning sensation). Wash hands before and after use. Imiquimod
Created by: Jakphooey



Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards