Save
Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't know
Remaining cards (0)
Know
0:00
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Pharm 36 Parasites

Pharm

QuestionAnswer
Accumulates in parasite food vacuole and binds to ferriprotoporphyrin IX->oxidative membrane damage. Tx and prophylaxis of Malaria. SE: Retinopathy, Prolonged QT, Pruritis. Contra: Visual field changes. Kills only blood stage and many strains resist Chloroquine
Accumulate in food vacuole and bind to ferriprotoporphyrin IX->oxidative memb damage and intercalates into DNA. Tx blood stage Malaria (P. falciparum) only. SE: Cinchonism (tinnitus, deaf, HA, N/V, visual prob), prolong QT, DIC, Rash. Contra: G6PD def, MG Quinine (Quinidine)
Tx and prophylaxis of Chloroquine resistant Malaria. SE: Seizure, Vivid dreams, Insomnia, Depress, Hallucinate. Contra: Psych probs. Mefloquine
First line for un/complicated malaria in combo w 2nd antimalarial agent tx (not prophy). SE: Hemolytic anemia, bradycardia. Artemisinin - Artesunate, Artemether-Lumefantrine
Inhibit plasmodial ETC. Kill both blood and liver stages of P. vivax and ovale. SE: Hemolytic anemia, leukopenia. Contra: G6PD def, Preg, RA, LE, bone marrow suppress. Primaquine
Inhibit plasmodial ETC. Combo w Proguanil or Doxycycline. For P. falciparum, Toxoplasmosis, Babesiosis. SE: GI distress, HA, High Liver enzymes. Atovaquone
Inhibit prot synth by binding to 30S. Combo w Quinine for Tx of Chloroquine-resist P. falciparum. SE: Photosensitivity, Tooth discolor (kids). Contra: Preg, <8 y/o kids Doxycycline, Tetracycline
Inhibit prot synth by binding to 50S. Combo w Quinine when Preg or <8 y/o for Tx of Chloroquine-resist Malaria. SE: C. difficile Pseudomembranous Colitis. Clindamycin
Inhibit plasmodial Dihydropteroate Synthetase and Dihydrofolate Reductase. Kills blood schizont stage (not gametocytes) of P. falciparum. SE: SJ synd, toxic epidermal necrolysis. Contra: Blood dyscrasia, Infants, Preg/breastfeed Sulfadoxine-Pyrimethamine
Inhibits plasmodial Dihydrofolate Reductase. Active against Hepatic (pre-blood) forms of P. falciparum and vivax. Combo w Chloroquine or Atovaquone. SE: Pancytopenia. Contra: Severe Renal impair Proguanil
When activated, forms cytotox cmpds that damage microbial prots, membs, and DNA. Active against Anaerobic bac, E. histolytica Amebiasis in tissues (not intraluminal). SE: Leuko/Thrombpenia, Ototox, Metallic taste. Contra: Disulfram effect w Alcohol, Preg Metronidazole - Tinidazole is better tolerated and requires shorter Tx duration
Inhibit DNA/RNA/Prot/Phosphlipid synth and Dihydrofolate Reductase. For African Trypanosomiasis, P. jiroveci (2nd line). SE: Pancreatitis, Nephrotox, Rash. Pentamidine
Inhibit RNA Polymerase and Glycerol Phosphate Dehydrogenase. For EARLY African Trypanosom. SE: Pruritus, Paresthesias, N/V Suramin
Inhibits Glycolysis and ATP productions. 1st line for LATE African Trypanosom (involves CNS). SE: Reactive Encephalopathy (w corticosteroids to lessen), Death (4-6%), Polyneuropathy (w thiamine to lessen) Melarsoprol
For WEST African Trypanosom (gambiense). SE: Myelosuppress, Seizure, Ototox. Also, for Hair Removal Eflornithine
For Chagas. SE: Pancytopenia, Convulsions, Anorexia. Nifurtimox
For Leishmaniasis. SE: Myelosuppress, Prolong QT, Rash. Sodium stibogluconate Meglumine antimonate
For Visceral Leishmaniasis and Cutaneous Lymphomas and skin metastat. SE: Leuko/Thrombcytosis. Contra: Breastfeed/Preg, Concurrent radiation Miltefosine
Increased GABA->Worm pharyngeal paralysis. For Onchocerciasis, Lymphatic filariasis, Strongyloides, Scabies. SE: Seizure, Mazzotti Rxn. Doesn't kill adult filarial worms-> can't cure Ivermectin
Inhibit tubulin polymerization. For Nematode infx. SE: Agranulocytosis, -penias. Dose reduction for renal insuff Albendazole (oral), Mebendazole
Increase worm membrane permeability to Ca-> contraction paralysis. For Schistosomiasis, Tapeworm, Liverfluke. Praziquantel
Kills adult Filarial worms (curative), excreted by kidneys (dose adjust w kidney probs). SE: Mazzotti Rxn (w heavy worm burden). Diethylcarbamazine
Created by: Jakphooey
 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards