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Pharm 39 Signal Canc
Pharm
Question | Answer |
---|---|
Reversible inhibitor of EGFR cytoplasmic tyrosine kinase domain (competes w ATP binding). For Non-small cell Lung cancer (espec. bronchoalveolar cell carcinoma). SE: Interstitial lung disease, corneal erosion. | Gefitinib |
Reversible inhibitor of EGFR cytoplasmic tyrosine kinase domain (competes w ATP binding). For Non-small cell Lung cancer, Pancreatic CA. SE: MI, DVT, GI hemorrhage. Greater survival benefit | Erlotinib |
Monoclonal antibody that binds to extracell domain of EGFR. For Colorectal and head and neck cancer. SE: Cardiac arrest, leukopenia, renal fail, rash (predictive of tumor response), diarrhea. better with irinotecan | Cetuximab |
Monoclonal antibody against HER2. Enhances efficacy of chemotherapy and reduces rates of recurrence. For Breast cancer (HER2 overexpress). SE: Cardiotox, Nephrotic synd, diarrhea, anemia. | Trastuzumab |
Small molecule tyrosine kinase inhibitor of BCR-ABL, C-KIT and PDGFR. For CML expressing Philadelphia chromosome [t(9;22)], GI stromal tumor expressing Kit. SE: Edema, myelosuppress, nausea, muscle cramps. | Imatinib |
Inhibit wild-type and mutant B-RAF. For Renal cell and Hepatocellular CA. SE: Cardiovasc disease, erythema multiforme, HTN, alopecia, hand-foot rash/pain. Activity against melanoma that have activating B-RAF mutations. Also inhibits VEGFR-2 and PDGFR-Beta | Sorafenib |
Binds and inhibits mTOR (no activation of translation). Prophylaxis for Renal transplant rejection. SE: susceptible to infx, lymphoma, malignancy, HTN, edema. Avoid co-admin w CYP3A4 drugs | Rapamycin |
Proteasome inhibitor. For Multi Myeloma, Mantle Cell Lymphoma. SE: Heart Fail, neuropathy, hypotension (relatively modest adverse effects) | Bortezomib |
Monoclonal IgG antibody against VEGF-A (inhibit angiogenesis). For Metastat Colorectal and Non-small Cell Lung cancers. SE: Arterial thromboembolism, impaired wound heal, neuropathy, dizzy, HA. | Bevacizumab |
Inhibit VEGFR-1, VEGFR-2, PDGFR (inhibit angiogenesis). For Renal cell CA and GIST. SE: Left ventricular dysfnx, anemia, inflamm of mucous membrane | Sunitinib |
Immunomodulator drug inhibits basic FGF induced angiogenesis (and costimulate T cells). For Multi Myeloma (in combo w Dexamethasone). SE: Teratogenic (flipper limb), Periph Neuropathy, edema. Contra: Preg or women capable of being preg or men w/o condom. | Thalidomide - Lenalidomide = analogue w enhanced TNF-Alpha inhibition and T cell costim. combo w bortezomib and dexamethasone for Multi Myeloma |
Anti-CD20 antibody. For B cell Non-Hodgkin's Lymphoma. SE: Immunosuppression. | Rituximab |