click below
click below
Normal Size Small Size show me how
Drugs for Spasticity
Drugs for Muscle Spasm and Spasticity
Question | Answer |
---|---|
Muscle relaxant: mechanism of action | Unclear, maybe from sedative properties of drugs |
Muscle relaxant: uses | Relieves localized spasm resulting from muscle injury. Decrease local pain and tenderness. Sedation |
Muscle relaxant: adverse effects (CNS) | Drowsiness, dizziness, lightheadedness |
Muscle relaxant: adverse effects (hepatotoxicity) | Tizanidine, Metaxalone, Chlorzoxazone |
Muscle relaxant: adverse effects (anticholinergic) | Cyclobenzaprine, orphenadrine can cause dry mouth, blurred vision, photophobia, urinary retention, constipation |
Baclofen: mechanism of action | Acts within spinal cord to suppress hyperactive reflexes. May mimic of GABA on spinal neurons |
Baclofen: uses | Reduces spasticity associated with multiple sclerosis, spinal cord injury, and cerebral palsy. Preferred over dantrolene when spasticity is associated with muscle weakness |
Baclofen: adverse effects | Drowsiness, dizziness, weakness, fatigue |
Baclofen (intrathecal): abrupt withdrawal | High fever, altered mental status, exaggerated rebound spasticity, muscle rigidity. Rarely, rhabdomylosis (muscle breakdown), multiple organ system failure, and death |
Diazepam: mechanism of action | Benzodiazapine. Act in CNS to suppress spasticity. May mimic GABA at receptors in spinal cord and brain |
Diazepam: adverse effects | Sedation |
Dantrolene: mechanism of action | DIrectly acts on skeletal muscle. Suppresses release of calcium from SR so muscles are less able to contract |
Dantrolene: uses | Spasticity associated with multiple sclerosis, spinal cord injury, and cerebral palsy. Also used for malignant hyperthermia |
Dantrolene: adverse effects | Hepatoxicity, muscle weakness, drowsiness, diarrhea |