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medication its influence
Question | Answer |
---|---|
define pharmocodynamics? | how a drug influences cell physiology |
define pharmocodynamics | mechanism of action...of a drug |
define pharmacokinetics? | how the drug enters my body, reach site of action then eliminated from my body. |
name a type of pharmacological action? | drugs which change the environment of body cells eg antacids/mylanta>neutralising stomach acidity. |
name a type of pharmacological action? | the drug binding to the receptors causing a physiological response. |
name a type of pharmacological action? | a pts functional state can influence that response...not absorbed/inactivated once absorbed. |
what is absorption? | what happens to a drug from the time it enters the body until it enters the circulating fluid. |
what is absorption? | iv will bypass the complication of absorption from other routes. |
explain active transport | the movement of substances across the cell membranne. |
an agonist is? | a drug that interacts directly with a receptor site to cause an effect. eg |
an agonist is? | Drugs generally work by interacting with receptors on the surface of cells or enzymes (which regulate the rate of chemical reactions) within cells.This is often referred to as a lock and key model. |
an agonist is? | Examples of agonists are morphine, nicotine, phenylephrine, and isoproterenol |
an agonist is? | Receptor and enzyme molecules have a specific three-dimensional structure which allows only substances that fit precisely to attach to it. This is often referred to as a lock and key model. |
an agonist is? | Most drugs work because by binding to the target receptor site, they can either block the physiological function of the protein, or mimics it's effect. |
an agonist is? | If a drug causes the protein receptor to respond in the same way as the naturally occurring substance, then the drug is referred to as an agonist. |
describe excretion? | removal of a drug from the body starts in the kidneys...can also occur through the skin, bile as in vomitting, lungs and feces. |
an antagonist does what? | a drug that interacts with a receptor but does not cause an effect, but blocks it. |
an antagonist does what? | they reduce the action of an agonist at the receptor site involved. |
an antagonist does what? | Receptor antagonists can be classified as reversible or irreversible. |
an antagonist does what? | Examples of antagonist drugs are: beta-blockers, such as propranolol. |
explain distribution? | the movement of a drug to body tissues. this drug distribution is dependant on the drugs solubility, perfusion of the area, cardiac output and plasma binding. |
what is 'first pass effect'? | the first pass effect allows the liver to metabolise or inactivate drugs and potentially harmful substances before distribution throughout the body. |
what is 'first pass effect'? | Metabolism of a drug during its passage from site of absorption [GI tract] into the systemic circulation [bloodstream]. Enter the liver via the hepatic portal vein before entering general circulation. |