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NS drugs--pharm

Bethanechol muscarinic agonist cholinesterase prototype treatment of postpartum and post-operative non-obstructive urinary retention
acetylcholine muscarinic agonist cholinesterase
methacholine muscarinic agonist cholinesterase
carbachol muscarinic agonist cholinesterase mitotic agent (small pupils) for glaucoma
Pilocarpine muscarinic agoinst natural alkaloid prototype treatment of glaucoma
muscarine muscarinic agonist natural alkaloid considered a toxin--from mushrooms
atropine muscarinic antagonist prototype natural alkaloid L-Hyoscyamine
scopalamine muscarinic antagonist prototype L-Hyoscine
CNS compounds (Anti-Parkinsons) Muscarinic antagonists benztropine trihexylphenidyl biperiden procyclidine
benztropine CNS compound (Anti-Parkinsons) Muscarinic antagonists
trihexylphenidyl CNS compound (Anti-Parkinsons) Muscarinic antagonists
biperiden CNS compound (Anti-Parkinsons) Muscarinic antagonist
procyclidine CNS compound (Anti-Parkinsons) Muscarinic antagonist
Muscarinic antagonists Urinary incontinence drugs oxybutynin tolteridine
oxybutynin Muscarinic antagonist Urinary incontinence drugs
tolteridine Muscarinic antagonist Urinary incontinence drugs
Muscarinic antagonists Inhalants Ipratropium Tiotropium
Ipratropium Muscarinic antagonist; bronchodilator; used for cholinergic-mediated bronchospasm related to COPD; causes dry mouth
Tiotropium Muscarinic antagonist; bronchodilator; significantly longer half-life; some selectivity for M3
Methylscopolamine bromide Muscarinic antagonist GI spasms
Homatropine methylbromide Muscarinic antagonist GI spasms and IBS
Prothantheline Muscarinic antagonist ulcer
Glycopyrrolate Muscarinic antagonist anti-vagal with anesthesia
Receptor subtype selective muscarinic antagonists pirenzepine (M1, M4 selective) acid-peptic disorders darifenacin (somewhat M3 selective) urinary incontinence
Tensilon test used to diagnose Myasthenia Gravis Edrophonium
Pralidoxime (2-PAM) treatment of organophosphate poisoning
Indirect muscarinic agonists treatment of glaucoma by targeting muscarinic receptors Echothiophate diisopropyl fluorophosphate
Indirect muscarinic agonists treatment of Myasthenia Gravis by targeting nicotinic receptors (do not cross BBB) neostigmine pyridostimine ambenonium
Indirect muscarinic agonists treatment of Alzheimer's Physostigmine Tacrine Donepezil Galantamine
Indirect muscarinic agonists Bug poisons Parathion malathion sevin chlorpyriphos
Indirect muscarinic agonists Human poisons Sarin Soman VX (dermal LD50 ~784ug)
Main classes of Indirect muscarinic agonists Quaternary amines carbamates Organophosphates
Indirect muscarinic agonists Quaternary amines Edrophonium very short-acting
Indirect muscarinic agonists carbamates neostigmine physostigmine intermediate to long-acting
Indirect muscarinic agonists organophosphates diisopropyl fluorophosphate very long acting (so slow its irreversible)
Nicotinic blockers acetylcholine succinylcholine pancuronium tubocurarine atracurium doxacurium
Nicotinic blocker prototype tubocurarine
Steroid-based neuromuscular blockers Pancuronium Pipecuronium Vecuronium Rocuronium
Nicotinic blocker that acts initially as a depolarizing agent, then it becomes a non-depolarizing agent succinylcholine
most notable effect of alpha-1 vasoconstriction
most notable effect of alpha-2 lowers BP inhibition of sympathetic activity
most notable effect of beta-1 stimulates the heart
most notable effect of beta-2 bronchodilation blood vessel dilation
Dobutamine beta-1 agonist increases cardiac output positive inotropic effect
Albuterol Terbutaline short-acting beta-2 agonists used for asthma/COPD
Salmeterol Formoterol long-acting beta-2 agonists used for asthma/COPD
Ritodrine beta-2 agonist tocolytic (uterine relaxer) used to treat premature labor
Isoproterenol prototypic non-selective beta agonist
Alpha-1 agonists nasal decongestants Pseudoephedrine Phenylephrine Oxymetazoline
tetrahydrozoline alpha-1 agonist gets red out of eyes by vasoconstriction
methoxamine Alpha-1 agonist treats hypotension vasoconstrictor
Mephenteramine Alpha-1 agonist direct and indirect acting (NE release) treats hypotension
Alpha-1 agonist direct and indirect acting (NE release) treats paroxysmal supraventricular tachycardia (vasocontriction causes reflex bradycardia) Metaraminol
Midodrine Alpha-1 agonist treats orthostatic hypotension
Norepinephrine (inject only) Alpha-1 agonist treats severe acute hypotension
Alpha-1 agonist effects tried for weight loss, but causes cataracts 2,4-dinitrophenol (DNP)
Alpha-1 agonist effects weight loss drugs amphetamine, methamphetamine phentermine phendimetrazine, phenmetrazine diethylpropion phenylpropanolamine (Ayds)
Alpha-2 agonists used in treatment of BP used in treatment of drug withdrawal/addiction clonidine guanabenz guanfacine
Tizanidine Alpha-2 agonist muscle relaxer
Apraclonidine Brimonide Alpha-2 agonists treatment of glaucoma--decrease aqueous humor production
false transmitter acts as alpha-2 agonist without much effect on alpha-1 receptor Methyldopa
Phenoxybenzamine Alpha-1 antagonist treatment for pheochromocytoma long-acting
Phentolamine Alpha-1 antagonist treatment for pheochromocytoma effect 5-7 hrs
Alpha-1 antagonists vasodilators work on alpha-1>>>alpha-2 Prazosin doxazosin terazosin tamsulosin
Prazosin Alpha-1 antagonist prototype vasodilators work on alpha-1>>>alpha-2
Yohimbine alpha-2 antagonist used for sexual dysfunction
Beta antagonist prototype blocks beta-1 and beta-2 propranolol
pindolol Beta antagonist intrinsic sympathomimetic activity partial agonist effects at beta-2
metoprolol Beta antagonist selective for beta-1 (cardio-selective)
labetalol Beta antagonist blocks beta receptors and alpha-1 ISA--partial agonist effects at beta-2
acebutolol Beta antagonist membrane stabalizing activity--may improve some cardiac arrhythmias
Cardio-selective beta blockers acebutolol atenolol esmolol metoprolol
Non-selective beta blockers labetalol nadolol pindolol propranolol timolol
beta blockers with ISA partial agonist effects at beta-2 acebutolol labetalol pindolol
beta blocker with shortest half-life (10 minutes) esmolol
Created by: simpsonan



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