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Adrenergic Pharm
Pharmacolgy Exam 2
| Question | Answer |
|---|---|
| What are the classes of sympathomimetics? | Alpha 1 & 2 agonists, Beta 1 & 2 agonists, dopamine receptors |
| What are the classes of sympatholytics? | Alpha 1 & 2 antagonists, Beta 1 & 2 antagonists, |
| What molecule inhibits tyrosine hydroxylase? | Metyrosine |
| what molecule inhibits VMAT from transporting dopamine into the vesicles? | Reserpine |
| what kind of molecules would block the reuptake of NE in the synaptic cleft? | cocaine, antidepressants |
| what molecules would block SNAPs and VAMPs | bretylium & guanethidine |
| What is the difference between direct acting and indirect acting agonists? | Direct acting drugs directly activate the receptor. Indirect acting drugs stimulate release, affect reuptake, or other |
| What is a mixed acting drugs? | Drugs that act both directly and indirectly (affect the receptor and the release or reuptake of the nt) |
| How are the actions of neurotransmitters ended? | Reuptake (~50%), metabolism (~50%), or taken up by other cells (glial cells) |
| how does cocaine effect the reuptake of NE? | blocks NET from reuptake of NE |
| how does amphetamine effect the reuptake of NE? | can cause NET to run backwards and actually pump out more NE into the synaptic cleft |
| What 2 enzymes metabolize catecholamines? | COMT and MAO (Catehol-O-CH3 transferase and Monoamine Oxidase) |
| How doe MAO's work? | deamination |
| How do COMT's work? | methylation |
| Where are COMT's located? | Kidney, liver, intestine, nervous tissue |
| COMT's mainly degrade catecholamines from where? | our diet |
| There are 2 types of MAO's (A & B). Where are MAO's found? | inside neurons and glia |
| What enzyme cascade are G proteins linked to? | Phospholipase C |
| Which enzyme cascade do Alpha 1 receptors use? | Phospholipase C |
| Which enzmye cascade do Beta receptors use? | adenylate cyclase |
| Which enzyme cascade do alpha 2 receptors inhibit? | adenylate cyclase |
| What is the most notable effect of A1 receptors? | vasoconstriction |
| What is the most notable effect of A2 receptors? | lowers bp |
| What is the most notable effect of B1 receptors? | cardiac stimulation |
| What is the most notable effect of B2 receptors? | bronchodilation, vasodilation |
| What is the most notable effect of dopamine receptors? | cardiac stimulation |
| If both alpha and beta receptors are being stimulated, clinically, which response would be observed? | alpha |
| What are the direct acting agonists of the adrenergic system? | NE, Epi, & DOPA |
| What receptors does NE bind to? | A1 & B1 |
| What receptors does Epi bind to? | A1, B1, B2 |
| What receptors does DOPA bind to? | B1 |
| What drug is selective for B1 and B2? | isoproterenol |
| Name some beta 2 agonists | albuterol, salmeterol, formoterol, terbutaline |
| What are albuterol, salmeterol, formoterol, terbutaline used to treat? | asthma/COPD |
Created by:
balyons01
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