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Nicotinic Pharm

Pharmacolgy Exam 2

QuestionAnswer
Where are nicotinic receptors found? What do they innervate? Nicotinic receptors are found in neuromuscular endplate, skeletal muscle, and autonomic ganglion cells
Ganglionic blockers are what kind of class of drugs? (muscarinic/nicotinic agonist/antagonist) Nicotinic antagonist
What do ganglionic blockers (nicotinic antagonists) do? block nicotinic receptors in the autonomic ganglia
What are ganglionic blockers used in the treatment of? acute, dissecting aortic aneurysm
To which class do hexamethonium, mecamylamine, and tetraethylammonium belong? ganglionic blockers
To which class does succinylcholine belong? Neuromuscular blockers - depolarizing agent
How do depolarizing neuromuscular blockers work? They depolarize the membrane of the skeletal muscle fiber persistently. This persistent depolarization makes the muscle fiber resistant to further stimulation by ACh.
Why is succinylcholine considered a "special case" Succinylcholine acts initially as a depolarizing agent, then it becomes a non-depolarizing agent
How do non-depolarizing neuromuscular blocks work? They do not depolarize the neuromuscular end plate. They bind to the receptor and keep the channel from opening.
What are some examples of non-depolarizing neuromuscular blocking drugs? Pancuronium, Tubocurarine, Atracurium, Doxacurium, Pipecuronium, Vecuronium, Rocuronium
What are the three phases of the neuromuscular channels? closed, open, resetting
Created by: balyons01
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