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Diuretic drugs

diuretic drugs

ClassDrugsSite of ActionMajor IndicationsAdverse affects
Loop Diuretics (20-25%) Furosemide, Bumetanide TAL (NaK2CL inhibitor) Pulm Edema, Resistant Edema Ototoxicity, vascular collapse, low Cl, Ca, K (with metabolic alkalosis), braking phenomenon (give Na to get it going again, counterintuitive), increase renin activity
Thiazides (5%) Hydrochlorothiazide Early Distal convoluted tubule (NaCl co transporter inhibitor Edema, HTN, CHF high Ca, low K (w/ metab alkalosis), carbohydrate intolerance, increase renin activity (not bad per se, but opposite of what you're trying to do)
Carbonic Anhydrase Inhibitors (1-3%) Acetazolamide proximal tubule Urinary alkalinazation, glaucoma, epilepsy hypokalemia, metabolic acidosis (HCO3 loss)
Potassium-sparing diuretics Spironolactone Late distal tubule, collecting duct (Inhibit aldosterone syn) Ascites, K+sparing effects, CHF hyperkalemia, gynecomastia, mentrual irregularities, increase renin activity
Osmotics diuretics mannitol, urea, glycerol Proximal tubule Cerebral edema Acute volume overload, low Na+/K+
Created by: milletbrock
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