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ABx mechanisms

therapeutics

QuestionAnswer
Penicillins Bind to transpeptidase enzymes in the bacterial cell and disrupt cell wall formation, bactericidal
Cephalosporins Bind to transpeptidase enzymes in the bacterial cell and disrupt cell wall formation, bactericidal
Aminoglycosides Bind to the 30S ribosomal subunit and inhibit bacterial protein synthesis, bactericidal
Tetracyclines Reversibly bind to the 30S ribosomal subunit and inhibit bacterial protein synthesis, bacteriostatic
Macrolide Reversibly bind to the 50S ribosomal subunit and inhibit bacterial protein synthesis, bacteriostatic
Lincosamides Reversibly bind to the 50S ribosomal subunit and inhibit bacterial protein synthesis, bacteriostatic
Fluoroquinolones Inhibit DNA gyrase which results in breakage of bacterial DNA, bactericidal
Glycopeptides Bind to the D-alanyl-D-alanine terminal residue in the growing peptidoglycan chain, inhibits cell wall formation, bactericidal
Trimethoprim/sulfamethoxazole Inhibits sequential steps in the formation of tetrahydrofolate in bacteria which inhibits purine synthesis, bacteriostatic
Nitroimidazoles reduced to a toxic intermediate that produces damage but interaction with bacterial DNA, bactericidal
Oxazolidinones inhibition of protein synthesis at the 50S ribosome, bacteriostatic
Streptogramin inhibit bacterial protein synthesis by irreversably binding to different sites on the 50S bacterial ribosomal subunit, bactericidial
Daptomycin irreversibly binds to the bacterial cell membrane, cacium dependent membrane insertion of molecule, rapidly depolarizes the cell membrane (efflux of K, destroys ion-concentration gradient), cell death
Fidaxomicin inhibits RNA polymerases
Created by: Kachmiel
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