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ARAs
Aldosterone Receptor Antagonists - Overview
Question | Answer |
---|---|
What are eplerenone and spironolactone approved for? | heart failure and hypertension |
What is spironolactone also indicated for? | Treatment of hypokalemia Treatment of hyperaldosteronism Treatment of edematous conditions for patients with cirrhosis of the liver |
Which ARA is the nonspecific aldosterone receptor antagonist associated with progestogenic and androgenic effects? | spironolactone |
What are progestogenic and androgenic effects? | gynecomastia erectile dysfunction menstrual irregularities hirsutism mastalgia |
Which ARA has lower affinity for androgen, progesterone, and glucocorticoid receptors? | eplerenone |
Which ARA has a lower incidence of adverse effects? | eplerenone |
Which side effect are both ARA's associated with? | hyperkalemia |