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RA drugs.

therapeutics

QuestionAnswer
Methotrexate (rheumatrex)non-biologic DMARD, 7.5-20 mg/week, supplement with folic acid, AE:ulcerative coilitis, diaherrea, alopecia, pneumonitis, SJS
Hydroxychloroquine (placquenil)non-biologic DMARD, po dosing with food/milk, vision changes, N/V/D, anemia
Leflunomide (arava)non-biologic DMARD, po dosing, no renal adjustment, AE: immunosuppression, sepsis, opportunistic infections, SJS, N/D, alopecia, HTN
sulfasalazine (azulfidine)non-biologic DMARD, po with food, AE: gi, SJS
Tofacitinib (xeljanz)non-biologic DMARD, po bid- adjust hepatically and renally, AE: inc hepatic enzymes, HA, opportunistic infections
adalimumab (Humira) biologic DMARD Anti-TNF, SC q2w (qw if not on MTX)AE: infection, injection site reaction, nausea
certolizumab pegol (cimzia)biologic DMARD Anti-TNF, SC, AE: infection, sepsis, TB, URI, UTI, HA, backpain, injection site reaction
etanercept (Enbrel)biologic DMARD Anti-TNF SC weekly, AE: URI, TB, injection site reaction, HA
infliximab (remicade)biologic DMARD Anti-TNF, IV with mtx, AE: serious infection, TB, URI, CHF, injection site reaction, fever, chills, myalgia
golimumab (simponi)biologic DMARD Anti-TNF, suppress T-cell activation, SC q monthly with mtx AE: serious infection, sepsis, TB,URI, Hep B, CHF, cns, injection site reaction, in hepatic enzymes
abatacept (orencia)biologic DMARD non-anti-TNF, IV loading dose then SC, AE: infusion related reactions, secondaary malignancy, HA
rituximab (rituxan) biologic DMARD non-anti-TNF, anti-Bcell monoclonal antibody, IV 2 doses with methylprednisolone, AE: fatal infusion reactions, SJS, TEN, cardiac failure
tocilizumab (actemra)biologic DMARD non-anti-TNF, IL6 inhibitor, IV with or without mtx, AE: serious infections, elevated AST/ALT, gastritis
anakinra (kineret) biologic DMARD, IL1 antagonist, SC daily (CrCL <30 give every 48 hr), AE: Injection site reactions, URI, sinusitis, HA, neutropenia, thrombocytopenia
Created by: Kachmiel
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