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CNS Receptors

Pharmacology 2 Exam #1 - Receptors and Neurotransmitters

QuestionAnswer
GABA-A Ionotropic. Inc Cl conductance
GABA-B Metabotropic. dec cAMP, inc K, dec Ca
Glycine alpha and beta subunits Ionotropic. Inc Cl conductance
AMPA (glutamate) Ionotropic. Inc Na, Inc K conductance (open both channels)
Kainate (glutamate) Ionotropic. Inc Na conductance
NMDA (glutamate) Ionotropic. Inc Na, Inc Ca conductance
mGlu group I (glutamate) (m1 and m5) Metabotropic. inc cAMP(1), inc Ip3/DAG/Ca, dec K
D1 Family (D1, D5) (dopamine) Metabotropic. Inc cAMP
D2 Family (D2, D3, D4) (dopamine) Metabotropic. Dec cAMP, inc K, dec Ca
Norepinephrine (excitatory) Metabotropic. Inc cAMP, inc Ip3/DAG/Ca
Norepinephrine (inhibitory) Metabotropic. dec cAMP, inc K, dec Ca
5-HT1 Metabotropic. dec cAMP, inc K conductance
5-HT2 Metabotropic. Inc IP3/DAG/Ca, dec K
5-HT3 Ionotropic. Inc Na conductance
5-HT 4-7 Metabotropic. Inc cAMP, dec K
H1 (histamine) Metabotropic. Inc IP3/DAG/Ca, dec K
H2 (histamine) Metabotropic. Inc cAMP, dec K
H3 Unknown. Inhibitory
Nicotinic (Alpha 2 - 10, beta 2 - 5) Ionotropic. Inc Na, Inc Ca,
Muscarinic (m1-m5) Metabotropic. Inc K(2), Dec K(1), dec cAMP, inc IP3/DAG/Ca
Enkephalins (Mu, Delta, and Kappa - opioid receptors) Metabotropic. Inc IP3/DAG/Ca, dec K
mGlu group II (glutamate) (m2, m3) Metabotropic. Dec cAMP, dec Ca, inc K
Created by: HugsAndKisses
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