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Top 300 (unfinished)

Brand, Generic, AEs, Indications, ADME, interactions, contraindications

BrandGenericAdverse EffectsClassificationMechanism of Action
Catapres/Catapres TTS Clonidine Hydrochloride Dry mouth, drowsiness, dizziness, headache, fatigue, edema, constipations, and impotence Hypertension stimulates central alpha-adrenergic receptors resulting in inhibition of bulbar sympathetic cardioaccelerator and sympathetic vasoconstrictor centers.
Diovan Valsartan HA, dizziness occur at same rate as pacebo Angiotensin II Antagonist for hypertension, heart failure (NYHA class II-IV) intolerant of ACE INH. Blocks the vasocontrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues.
Diovan-HCT Valsartan and Hydrochlorothiazide Dizziness, viral infection, fatigue, pharyngitis, coughing and diarrhea. Angiotensin II Antagonist and thiazide diuretic. Hypertension Blocks the vasocontrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor. HCTZ inhibits the reabsorption of sodium and chloride at the distal renal tubule.
Hyzaar Losartan Potassium and Hydrochlorothiazide Upper respiratory infection, dizziness, cough and back pain. Angiotensin II Antagonist and thiazide diuretic. Hypertension Blocks the vasocontrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor. HCTZ inhibits the reabsorption of sodium and chloride at the distal renal tubule.
Hytrin Terazosin HCl ASthenia, palpitations, nausea, HA, nasal congestion, peripheral edema, and dizziness Antihypertensive/BPH treatment Decreases total peripheral resistance by competitvely blocking alpha-1-adrenoreceptors.
Tiazac Diltiazem HCl HA, edema, pain, asthenia, dizziness, dyspepsia, pharyngitis, dyspnea, infection, nausea and rash, diarrhea, constipation, palpitations, nervousness, rhinitis, and somnolence. Calcium Channel Blocker/Antihypertensive CCB that inhibits the influx of calcium ions across membranes (slow channels) which: dilates coronary arteries and arterioles, inhibits coronary spasm, lowers arterial blood pressure, slows SA and AV conduction and prolongs AV node ERP and FRP.
Isoptin (SR) Verapamil HCl Hypotension, peripheral edema, dizziness, HA, constipation, and nausea. Calcium Channel Blocker for treatment of vasospastic angina, unstable angina, and chronic stable angina, essential HTN, supraventricular tachyarrhthmias. (SR form is only for hypertension) CCB that inhibits the influx of calcium ions across membranes (slow channels) which: dilates coronary arteries and arterioles, inhibits coronary spasm, lowers arterial blood pressure, slows SA and AV conduction and prolongs AV node ERP and FRP.
Lotrel Amlodipine Besylate and Benazepril HCl COUGH, HA, dizziness, edema, angioedema, nausea, flushing, fatigue, and abd. pain. Calcium Channel Blocker and ACE Inh for hypertension Inhibits influx of calcium ions across slow channel membranes in vascular smooth and cardiac muscle. ACE inh decreases plasma angiotensin II which leads to dec. aldosterone secretion resulting in dec. peripheral arterial resistance.
Lotensin HCT Benazepril HCl and HCTZ dizziness, fatigue, cough, somnolence, impotence and nausea. ACE inh/thiazide diuretic/Antihypertensive ACE inh decreases plasma angiotensin II which leads to dec. aldosterone secretion resulting in dec. peripheral arterial resistance. HCTZ inhibits the reabsorption of sodium and chloride at the distal renal tubule.
Lotensin Benazepril HCl Cough, HA, dizziness, angioedema, fatigue, and nausea ACE inh for hypertension Inhibits ACE which converts angiotensin I to II (potent vasoconstrictor). ACE inh decreases plasma angiotensin II which leads to dec. aldosterone secretion.(may cause inc in serum potassium) Net result is dec. in peripheral arterial resistance.
Mavik Trandolapril Cough, dizziness, dyspepsia, asthenia, myalgia, and bradycardia. ACE inh for hypertension/or for pts with L-ventricular systolic dysfuction or who are symptomatic from CHF w/in 1st few days after an acute MI. Trandoolapril is prodrug of trandolaprilat which converts angiotensin I to II (potent vasoconstrictor). ACE inh decreases plasma angiotensin II which leads to dec. aldosterone secretion.(may cause inc in serum potassium) Net result is dec. in peripheral a
Monopril Fosinopril Sodium cough, angioedema, fatigue, nausea, vomiting and diarrhea. ACE INH./Antihypertensive or treatment of CHF converts angiotensin I to II (potent vasoconstrictor). ACE inh decreases plasma angiotensin II which leads to dec. aldosterone secretion.(may cause inc in serum potassium) Net result is dec. in peripheral arterial resistance.
Prinivil Lisinopril cough, angioedema, fatigue, nausea, vomiting and diarrhea. ACE INH/Antihypertensive or for treatment of CHF converts angiotensin I to II (potent vasoconstrictor). ACE inh decreases plasma angiotensin II which leads to dec. aldosterone secretion.(may cause inc in serum potassium) Net result is dec. in peripheral arterial resistance.
Ziac Bisoprolol Fumarate and Hydrochlorothiazide fatigue, HA, dizziness, diarrhea B-Blocker/thiazide diuretic/antihypertensive Beta-1-selective adrenergic blocking agent w/out significant membrane stabilizing or ISAs. High doses cause B-2-adrenergic blocking properties. HCTZ blocks sodium and chloride reabsorption in the distal renal tubule.
Vasotec Enalapril Maleate HA, dizziness, fatigue, diarrhea, rash, hypotension, cough, nausea, and orthostatic effects. ACE inhibitor/Antihypertensive/treatment of CHFand asymptomatic L-ventricular dysfunction Prodrug of enalaprilat that converts angiotensin I to II (potent vasoconstrictor). ACE inh decreases plasma angiotensin II which leads to dec. aldosterone secretion.(may cause inc in serum potassium) Net result is dec. in peripheral arterial resistance.
Zestril lisinopril cough, angioedema, fatigue, nausea, vomiting and diarrhea. ACE inhibitor/Antihypertensive/adjunctive therapy for CHF in pts not responding to diuretics and dig./treatment of hemodynamically stable pts w/in 24 hours of acute MI. converts angiotensin I to II (potent vasoconstrictor). ACE inh decreases plasma angiotensin II which leads to dec. aldosterone secretion.(may cause inc in serum potassium) Net result is dec. in peripheral arterial resistance.
Zestoretic lisinopril and HCTZ dizziness, HA, fatigue, cough, diarrhea ACEI/thiazide diuretic/Antihypertensive lisinopril converts angiotensin I to II (potent vasoconstrictor). ACE inh decreases plasma angiotensin II which leads to dec. aldosterone secretion(may cause inc in serum potassium). HCTZ blocks sodium and chloride reabsorption in the distal renal tubule.
Cardizem Diltiazem HCl peripheral edema, bradycardia,k flushing, HA, dizziness, astenia,k and aV block Calcium Channel Blocker/Antihypertensive/treatment of angina due to coronary artery spasm and chronic stable angina/temporary control of atrial fibrillation or atrial flutter and rapid conversion of paroxysmal suprventricular tachycardias. inhibits the influx of calcium ions across slow channel membranes, which dilates coronary arteries and arterioles, inhibits coronary spasm, lowers arterial blood pressre, slows AV node ERP/FRP
Norvasc Amlodipine Besylate edema, flushing, HA, fatigue, and abdominal pain CCB/antihypertensive inhibits the influx of calcium ions across slow channel membranes, which dilates coronary arteries and arterioles, decreases peripheral vascular resistance and inhibits coronary spasm.
Plendil Felodipine Peripheral edema, HA, flushing, palpitations, dizziness, fatigue, cough, and URIs CCB/Antihypertensive inhibits the influx of calcium ions across slow channel membranes,which decreases peripheral vascular resistance and modestly increases in heart rate.
Procardia Nifedipine Peripheral and pulmonary edema, palpitations, hypotension, dizziness, giddiness, headache, weakness, rash, nausea, flushing, nasal congestion, dyspnea, muscle crampes, and cough. CCB/Antihypertensive/treatment of vasospastic angina and chronic stable angina inhibits the influx of calcium ions across slow channel membranes, which dilates coronary arteries and arterioles, inhibits coronary spasm, and dilates peripheral arterioles which lowers peripheral resistance.
Aldactone Spironolactone Diarrhea, drowsiness, HA, amenorrhea, WEAKNESS, PARESTHESIA, MENTAL CONFUSION, DRY MOUTH, MUSCLE CRAMPS, hirsutism, urticaria, impotence, gynecomastia, nausea, and vomiting Potassium Sparing Diuretic/treatment of edema due to CHF or nephrotic syndrome and cirrhosis of the liver accompanies by edema and/or ascites/Antihypertensive/diagnosis of Primary Aldosteronism/treatment of primary hyperaldosteronism competitively antagonizes aldosterone, primarlily at the aldosterone-dependent Na/K exhange sites in the distal convoluted renal tubule.
Demadex Torsemide excessive urination/hypotension Loop Diuretic/treatment of edema from CHF or CRF/edema assoc. w/ hepatic cirrhosis/Antihypertensive inhibits the Na/K/2Cl carrier system in the lumen of the thick ascending portion of the loop of Henle. Increases excretion of sodium, chloride, and water, but does not significantly alter glomerular filtration rate, renal plasma flow, or acid-base balance
Bumex Bumetanide dizziness, hypotension, muscle cramps, weakness, impaired hearing , hyperuricemia, hypochloremia, hyponatremia, hypokalemia, azotemia, and hyperglycemia. Loop Diuretic/treatment of edema assoc. w/ CHF, cirrhosis of liver, and nephrotic syndrome inhibits reabsorption of Na/Cl in the ascending limb of the loop of Henle. Diuretic action also in the proximal tubule, but not noticeably in the distal tubule.
Lasix Furosemide Dizziness, orthostatic hypotension, dry mouth, Hearing loss, nausea, vomiting, weakness, muscle cramps, paresthesia, anemia, photosensitivity, purpura, rash, and hyperglycemia. Loop Diuretic/treatment of edema assoc. w/ CHF, cirrhosis of liver, and nephrotic syndrome/Antihypertensive/acute pulmonary edema (IV only) inhibits reabsorption of Na/Cl in the proximal and distal tubules, but more importantly in the loop of Henle.
Dyazide Triamterene and HCTZ dry mouth, muscle cramps, N&V, weakness, dizziness, orthostatic hypotension, GI distress including diarrhea and constipation, hyperglycemia, photosensitivity, impotence, rash, and transient blurred vision. Combination Diuretic/Antihypertensive/adjunctive treatment for edema assoc. w/ CHF, hepatic cirrhosis, nephrotic syndrome, and in corticosteroid and estrogen induced edema and idiopathic edema. triamteren inhibits the reabsorption of Na in exchange for potassium at the distal renal tubule. HCTZ inhibits the reabsorption of Na/Cl at the distal renal tubule.
Hydrochlorothiazide Hydrochlorothiazide dry mouth, muscle cramps, N&V, weakness, dizziness, orthostatic hypotension, GI distress including diarrhea and constipation, hyperglycemia, photosensitivity, impotence, rash, and transient blurred vision. thiazide diuretic/antihypertensive/treatment of edema assoc. w/ CHF, hepatic cirrhosis, corticosteroid and estrogen therapy, or various forms of renal dysfunction. inhibits the reabsorption of sodium and chloride at the distal renal tubule
Maxzide Triamterene and HCTZ dry mouth, muscle cramps, N&V, weakness, dizziness, orthostatic hypotension, GI distress including diarrhea and constipation, hyperglycemia, photosensitivity, impotence, rash, and transient blurred vision. Combination Diuretic triamteren inhibits the reabsorption of Na in exchange for potassium at the distal renal tubule. HCTZ inhibits the reabsorption of Na/Cl at the distal renal tubule.
Zaroxolyn Metolazone dry mouth, muscle cramps, N&V, weakness, dizziness, orthostatic hypotension, GI distress including diarrhea and constipation, hyperglycemia, photosensitivity, impotence, rash, and transient blurred vision. Quinazoline/Diuretic/Antihypertensive/therapy of edema assoc. w/ CHF or various forms of renal dysfunction inhibits the reabsorption of sodium and chloride at the cortical diluting site and in the proximal convoluted tubule.
Crestor Rosuvastatin Calcium myalgia, constipation, asthenia, abdominal pain, and nausea. Antihyperlipidemic/Adjunctive therapy to reduce elevated toal-C, LDL-C, ApoB, nonHDL-C, and TG levels and to inc. HDL-C in pts w/ primary hyperlipidemia and mixed dyslipidemia/reduce LDL-C, total-C, and ApoB in pts w/ homozygous familial lipidemia (adjunc selective, competitive inh. of HMG-CoA redutase.(enzyme is responsible for conversion of HMGCoA to mevalonate). Inc. # of LDL receptors on cell surface, theraby inc. uptake and catabolism of LDL and inh. the hepatic synth. of VLDL
Created by: schummster
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