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Pharm 13 Dopamine

Pharm

QuestionAnswer
Dopamine precursor, for Parkinsons. SE: Dyskinesia. almost always given with carbidopa. continued use results in tolerance and sensitization --> on/off phenomenon. Levodopa
dopamine R agonist, for Parkinsons. SE: dyskinesia, extrapyramidal movements, hallucinations, wild dreams. Less frequent dosing. Many use it as first line d/t longer time before on/off phenom especially in younger pts. Pramipexole, Ropinirole (also for restless legs)
MAO-B Inhibitor for Parkinsons. SE: B Branch Block, dyskinesia, insomnia, confusion. Contra: Concomitant use of a bunch o stuff and Pheochromocytoma. selective for MAO-B at low dose, but also inhibits MAO-A at high dose. Forms tox metabolite amphetamine Selegiline (Rasagiline does not form tox metab)
COMT Inhibitor for Parkinsons. SE: dyskinesia, hallucinations, liver fail, wild dreams. Contra: Liver disease. Crosses BBB Tolcapone
COMT Inhibitor for Parkinsons, most widely used. For Parkinsons. SE: dyskinesia, dyspepsia, wild dreams, sleep disorder. Does not cross BBB, remains in periphery. Entacapone
Antiviral used to treat Flu A and levodopa induced dyskinesias. SE: neuroleptic malignant synd, exacerbate mental disorder, insomnia, hallucinations. Amantadine
Muscarinic R ANtagonists, for Parkinsons. SE: angle closure glaucoma, psychosis, dizzy. Contra: Narrow angle glaucoma, younger than 3. Best at treating tremors. Trihexyphenidyl, Benztropine
Typical antipsychotic antagonizes mesolimbic D2 receptors. SE: Parkinson-like symps, neuroleptic malignant synd=catatonia, stupor, fever, autonom insability), tardive dyskinesia=repetitive involuntary stereotyped movements of face/arms/trunk), xerostomia Chlorpromazine, Fluphenazine (can be IM every 3-4 wks), and other -zines
Typical antipsychotic also for Tourettes. SE: parkinsons, neuroleptic malignant synd, tardive dyskinesia, antichol sympt. widely used butyrophenone. Haloperidole (decanoate ester given IM every 3-4 wks), also Pimozide(has a bunch o Contras)
Atypical antipsych, antagonizes D2 and 5-HT2, also for Bipolar. SE: less extrapyramidal symps than typical and more effective at treating negative schizo symps. Risperidone
Atyp antipsych antags D2 and 5-HT2 and D4 for schizo that other drugs don't work. SE: agranulocytosis and seizures, as well as mild extrapyramidal symps, antichol symps, sedation, weight gain. Contra: Myeloprolif Clozapine
Created by: Jakphooey
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