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Pharm 9 Cholinergics
Pharm
| Question | Answer |
|---|---|
| Inhibits acetylcholine synth, store, release. For focal dystonias, torticollis, achalasia, strabismus, blepharospasm, wrinkles, hyperhidrosis. SE: arrhythmia, syncope, hepatotox. degrades synaptobrevin and prevents vesicle fusion w/ presynaptic axon term | Botulinum Toxin |
| inhibit acetylcholine degradation by acetylcholinesterase (AChE). for differentiating myasthenia gravis and Lambert-Eaton synd (improves muscle weakness with MG, no effect on LE). SE: Seizure, bronchospasm, bradycardia, salivation, lacrimation. short act | Edrophonium |
| Inhibit AChE. For glaucoma, myasthenia gravis. SE: seizure, bradycardia, salivation, lacrimation, sweat. longer acting | Neostigmine, Pyridostigmine, Ambenonium |
| Inhibit AChE. For reversing antichol toxicity. Nonpolar structure. SE: seizure, salivation, lacrimation, sweat. | Physostigmine |
| Inhibit AChE. For Alzheimers and Dementia. SE: D/N/V, vivid dreams. | Tacrine, Donepezil, Galantamine, Rivastigmine |
| Muscarinic R Agonist. For diagnosing asthma. SE: dyspnea, dizzy, pruritis. Contra: heart attack/stroke, aortic aneurysm. Highly resistant to AChE and selective for cardio muscarinic receptors | Methacholine |
| Muscarinic R Agonist. For Glaucoma (non closed angle). SE: sweat, shiver, nausea. not used systemically b/c of high nicotinic action. | Carbachol |
| Muscarinic R Agonist. For Urinary tract motility. SE: sweat, shiver, frequent pee. | Bethanechol |
| Mucarinic R Agonist. For Xerostomia in Sjogrens. SE: sweat, shiver. | Pilocarpine, Cevimeline |
| Nicotinic R Agonist. For inducing depolarizing neuromuscular blockade before surgery/intubation. SE: Bradycardia, rhabdomyolysis, rigid muscles. Contra: UMN injury. | Succinylcholine |
| Muscarinic R ANtagonist. For AChE overdose, bradycardia, antidote to mushroom poison. SE: arrhythmia, coma, tachycardia, constipation, xerostomia. Contra: Narrow-angle glaucoma. Comes from Atropa belladonna. | Atropine |
| Musc R ANtagonist. For motion sickness. SE: somnolence, xerostomia. Contra: N-A glaucoma. Significant CNS effects (psychosis). Patch | Scopolamine |
| Musc R Antag. For PUD. SE: arrhythmia, constipation, xerostomia, decreased sweat. Contra: GI obstruct, N-A glaucoma. | Pirenzepine, Methscopolamine, Glycopyrrolate |
| Musc R ANtag. for COPD/Asthma. SE: paralytic ileus, bad taste. | Tiotropium (better), Ipratropium |
| Musc R ANtag. For Overactive bladder/urge incontinence. SE: Constipation, diarrhea, dry mouth. Contra: N-A glaucoma, urinary retention. | Nonspec: Oxybutynin, propantheline, Toterodine, Fesoterodine, Trospium. Spec M3 R antags: Darifenacin, Solifenacin (less dry mouth and constipation). |
| Nicotinic R ANtag. Nondepolarizing neuromuscular blockade for surgery/intubation. SE: HTN, tachycardia, salivation. | Long acting: Pancuronium, Tubocurarine Int acting: Vecuronium, Rocuronium Short acting: Mivacurium |
| Nicotinic R ANtag. For HTN w/ aortic dissection. SE: paralytic ileus. | Trimethaphan (don't take w/ asphyxia, neonates, shock) Mecamylamine (don't take w/ glaucoma, heart attack, pyloric stenosis, sulfonamides) |
Created by:
Jakphooey
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