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Serotonin +Histamine

Pharmacology Immune System

QuestionAnswer
How is histamine formed? decarboxylation of L-histidine to histamine by histidine decarboxylase
where is histamine located? mast cells, basophils, nervous system (NT), and GI system (enterochromaffin like (ECL) cells- gastric acid secretagogue
H1 (location) blood vessels, smooth muscle, heart, CNS
H2 (location) gastric mucosa, heart, uterus, CNS
H3 (location) airways, GI tract, CNS
H4 bone marrow, peripheral blood leukocytes, spleen, thymus, colon
triple response intradermal injection- red spot, flush/flare, wheal
Diphenhydramine (benadryl) (generation?) FGA
chlorpheniramine (Chlor-Trimenton) (generation?) FGA
brompheniramine (Dimetapp) (generation?) FGA
clemastine (Travist) FGA
loratadine SGA
Cetirizine SGA
Fexofenadine SGA
Desloratadine SGA
How is serotonin formed? Hydroxylation of L-tryptophan
Where is serotonin? GI (~90%, enterochromaffin cells), platelets, CNS
How is serotonin metabolized? by MAO(A)
What is the receptor for serotonin? 5-HT
Created by: Kachmiel
Popular Pharmacology sets

 

 



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