Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Don't know
Know
remaining cards
Save
0:01
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Inflammation+Immune

Inflamation and the Immune System- Pharmacology

QuestionAnswer
Innate Immune System 1st line of defense (physical, biochemical, cellular compponets, release of histamine, phagocytosis of bacteria
adaptive immune system specific response, antibodies, cytotoxic t cells
lymphoid stem cell gives rise to B and T cells
myeloid stem cell gives rise to neutrophils, eosinophils, etc
neutrophil phagocytic cells which destroy bacteria
eosinophil defense against parasitic infections
basophil circulating cells similar to mast cells, bind IgE antibody and release histamine (allergic response)
mast cell tissue-resident cells similar to basophils, bind IgE antibody and release histamine (allergic response)
antigen presenting cells process protiens of invading agent and display on cell surface so that antibodies and cytotoxic t cells can recognize and destroy
macrophages tissue resident process and present antigenic fragments to T cells
dendritic cells found in lymphoid tissue, initiate adaptive response
Major histocompatibility complex (MCH) way for cells to present protien fragments
MHC class 1 display cytosolic protiens
MCH class 2 display protein fragments from endocytic vesicles
Humoral immunity part of adaptive immunity, B-cells make antibodies and antibodies go to extracellular infectious agents (bacteria)
B cells antigen presenting cells that synthesize and secrete antibodies
cellular immunity part of adaptive immunity, involves t cells
perforins pore-forming proteins- a protein that T cells use to destroy infected cells
granzymes protease which induces apoptosis in viral infected cells
fasligand transmembrane protien from tumor necrosis factor family, binding induces apoptosis
tolerance carefully regulated process to make sure cells of the immune system do not recognize self
costimulation multiple signals necessary to initiate an immune response, provides a way the immune system can limit response
histamines synthesized, stored and released from mast cells and basophils, dilate arterioles and postcapillary venules, constrict viens, contract endothelial cells
eicosanoids prostaglandins and leukotrienes, some pro-inflammatory while others limit the reaction
cytokines protiens that act to enhance the immune system
interleukins cytokine- important for acute inflammation (IL-1, TNF)
chemkines cytokine- help recruit cells to injured area
chemotaxis recruitment of immune system cells
phagocytosis leukocytes are activated then ingest forgiwn substance coated with opsonins- binding enhancers
resolution healing and scar formation through angiogenesis and granulation tissue
Type 1 immune response immediate hypersensitivity (sec-min), mediated by IgEm anaphylaxis, asthma, hay fever, urticaria (hives)
Type 2 immune response (hr-days) formation of antigen antibody complex, mediated by IgG or Ig immunoglobins
Type 3 immune response (hr-days)presence of eleevated levels of antigen-antibody complexes deposited on basement membrane in tissues and vessels, IgG, IgM, recruit neutrophils, skin rases, glomerulonephritis, arthritis, lupus
Type 4 immune response delayed 2-3 days after exposure, cell mediated instead of antibody mediated, T cells, contact dermatitis, diabetes
Created by: Kachmiel